Mechanistic Studies of the Multiple Myeloma and Melanoma Cell-Selective Toxicity of the Rpn13-Binding Peptoid KDT-11.
Sign Up to like & getrecommendations! Published in 2020 at "Cell chemical biology"
DOI: 10.1016/j.chembiol.2020.08.008
Abstract: We previously reported a peptoid ligand for the proteasomal ubiquitin receptor Rpn13 called KDT-11 and demonstrated that this compound is toxic to multiple myeloma cells, but not non-malignant cells. Here, we show that KDT-11 decreases… read more here.
Keywords: studies multiple; kdt; multiple myeloma; mechanistic studies ... See more keywords
Proteomic Analysis Identifies Mechanism(s) of Overcoming Bortezomib-Resistance Via Targeting Ubiquitin Receptor Rpn13
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DOI: 10.1182/blood-2019-130236
Abstract: Introduction Our studies have focused on delineating ubiquitin proteasome pathway signaling with a goal to identify and validate novel therapeutic targets to overcome proteasome-inhibitor-resistance in multiple myeloma (MM). Our siRNA screening studies showed ubiquitin Receptor… read more here.
Keywords: bortezomib resistance; sod1; ra190; rpn13 ... See more keywords
Structure-function analyses of candidate small molecule RPN13 inhibitors with antitumor properties
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DOI: 10.1371/journal.pone.0227727
Abstract: We sought to design ubiquitin-proteasome system inhibitors active against solid cancers by targeting ubiquitin receptor RPN13 within the proteasome’s 19S regulatory particle. The prototypic bis-benzylidine piperidone-based inhibitor RA190 is a michael acceptor that adducts Cysteine… read more here.
Keywords: cell lines; ra375; piperidone; function ... See more keywords