Target Fishing Reveals a Novel Mechanism of 1,2,4-Oxadiazole Derivatives Targeting Rpn6, a Subunit of 26S Proteasome.
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DOI: 10.1021/acs.jmedchem.1c02210
Abstract: 1,2,4-Oxadiazole derivatives, a class of Nrf2-ARE activators, exert an extensive therapeutic effect on inflammation, cancer, neurodegeneration, and microbial infection. Among these analogues, DDO-7263 is the most potent Nrf2 activator and used as the core structure… read more here.
Keywords: rpn6; 26s proteasome; oxadiazole derivatives; mechanism ... See more keywords