Disputed rpoB Mutations in Mycobacterium tuberculosis and Tuberculosis Treatment Outcomes
Sign Up to like & getrecommendations! Published in 2021 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.01573-20
Abstract: Discordant results between genotypic drug susceptibility testing (gDST) and phenotypic DST (pDST) for Mycobacterium tuberculosis isolates with disputed mutations affect rifampin (RIF)-resistant (RR) and multidrug-resistant (MDR) tuberculosis (TB) treatments due to a lack of practical… read more here.
Keywords: treatment outcomes; rpob mutations; mycobacterium tuberculosis; tuberculosis ... See more keywords
Low-Level Rifampin Resistance and rpoB Mutations in Mycobacterium tuberculosis: an Analysis of Whole-Genome Sequencing and Drug Susceptibility Test Data in New York
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Clinical Microbiology"
DOI: 10.1128/jcm.01885-20
Abstract: Rapid and reliable detection of rifampin (RIF) resistance is critical for the diagnosis and treatment of drug-resistant and multidrug-resistant (MDR) tuberculosis. Discordant RIF phenotype/genotype susceptibility results remain a challenge due to the presence of rpoB… read more here.
Keywords: rpob mutations; rif resistance; level; resistance ... See more keywords
Reevaluating Rifampicin Breakpoint Concentrations for Mycobacterium tuberculosis Isolates with Disputed rpoB Mutations and Discordant Susceptibility Phenotypes
Sign Up to like & getrecommendations! Published in 2022 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.02087-21
Abstract: Tuberculosis (TB) is still one of the world's leading infectious disease killers. The early and accurate diagnosis of RIF resistance is necessary to deliver timely and appropriate treatment for TB patients and improve their clinical… read more here.
Keywords: rif; rpob mutations; tuberculosis; resistance ... See more keywords
Frequency and Type of Disputed rpoB Mutations in Mycobacterium tuberculosis Isolates from South Korea
Sign Up to like & getrecommendations! Published in 2017 at "Tuberculosis and Respiratory Diseases"
DOI: 10.4046/trd.2017.80.3.270
Abstract: Background A disputed rpoB mutation is a specific type of rpoB mutation that can cause low-level resistances to rifampin (RIF). Here, we aimed to assess the frequency and types of disputed rpoB mutations in Mycobacterium… read more here.
Keywords: rpob mutations; south korea; tuberculosis; rpob mutation ... See more keywords