NifA is the master regulator of both nitrogenase systems in Rhodobacter capsulatus
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DOI: 10.1002/mbo3.921
Abstract: Rhodobacter capsulatus fixes atmospheric nitrogen (N2) by a molybdenum (Mo)‐nitrogenase and a Mo‐free iron (Fe)‐nitrogenase, whose production is induced or repressed by Mo, respectively. At low nanomolar Mo concentrations, both isoenzymes are synthesized and contribute… read more here.
Keywords: capsulatus; rhodobacter capsulatus; nifa master; rpon ... See more keywords
Targeting the alternative sigma factor RpoN to combat virulence in Pseudomonas aeruginosa
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DOI: 10.1038/s41598-017-12667-y
Abstract: Pseudomonas aeruginosa is a Gram-negative, opportunistic pathogen that infects immunocompromised and cystic fibrosis patients. Treatment is difficult due to antibiotic resistance, and new antimicrobials are needed to treat infections. The alternative sigma factor 54 (σ54,… read more here.
Keywords: alternative sigma; factor rpon; pseudomonas aeruginosa; virulence ... See more keywords
Blocking RpoN reduces virulence of Pseudomonas aeruginosa isolated from cystic fibrosis patients and increases antibiotic sensitivity in a laboratory strain
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DOI: 10.1038/s41598-019-43060-6
Abstract: Multidrug-resistant organisms are increasing in healthcare settings, and there are few antimicrobials available to treat infections from these bacteria. Pseudomonas aeruginosa is an opportunistic pathogen in burn patients and individuals with cystic fibrosis (CF), and… read more here.
Keywords: cystic fibrosis; pseudomonas aeruginosa; virulence; reduces virulence ... See more keywords
Potentiation of Aminoglycoside Lethality by C4-Dicarboxylates Requires RpoN in Antibiotic-Tolerant Pseudomonas aeruginosa
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DOI: 10.1128/aac.01313-19
Abstract: Antibiotic tolerance contributes to the inability of standard antimicrobial therapies to clear the chronic Pseudomonas aeruginosa lung infections that often afflict patients with cystic fibrosis (CF). Metabolic potentiation of bactericidal antibiotics with carbon sources has… read more here.
Keywords: rpon; pseudomonas aeruginosa; tob fum; potentiation ... See more keywords
RpoN Promotes Pseudomonas aeruginosa Survival in the Presence of Tobramycin
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DOI: 10.3389/fmicb.2017.00839
Abstract: Pseudomonas aeruginosa has developed diverse strategies to respond and adapt to antibiotic stress. Among the factors that modulate survival in the presence of antibiotics, alternative sigma factors play an important role. Here, we demonstrate that… read more here.
Keywords: phase; rpos; presence; tobramycin ... See more keywords
Experimental Evolution of Campylobacter jejuni Leads to Loss of Motility, rpoN (σ54) Deletion and Genome Reduction
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DOI: 10.3389/fmicb.2020.579989
Abstract: Evolution experiments in the laboratory have focused heavily on model organisms, often to the exclusion of clinically relevant pathogens. The foodborne bacterial pathogen Campylobacter jejuni belongs to a genus whose genomes are small compared to… read more here.
Keywords: evolution; deletion; rpon; motility ... See more keywords
Role of two RpoN in Bradyrhizobium sp. strain DOA9 in symbiosis and free-living growth
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DOI: 10.3389/fmicb.2023.1131860
Abstract: RpoN is an alternative sigma factor (sigma 54) that recruits the core RNA polymerase to promoters of genes. In bacteria, RpoN has diverse physiological functions. In rhizobia, RpoN plays a key role in the transcription… read more here.
Keywords: rpon; free living; two rpon; role two ... See more keywords
The Regulatory Functions of σ54 Factor in Phytopathogenic Bacteria
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DOI: 10.3390/ijms222312692
Abstract: σ54 factor (RpoN), a type of transcriptional regulatory factor, is widely found in pathogenic bacteria. It binds to core RNA polymerase (RNAP) and regulates the transcription of many functional genes in an enhancer-binding protein (EBP)-dependent… read more here.
Keywords: rpon; functions factor; factor phytopathogenic; phytopathogenic bacteria ... See more keywords