Inhibition of AURKA Reduces Proliferation and Survival of Gastrointestinal Cancer Cells With Activated KRAS by Preventing Activation of RPS6KB1.
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DOI: 10.1053/j.gastro.2018.10.030
Abstract: BACKGROUND & AIMS Activation of KRAS signaling and overexpression of the aurora kinase A (AURKA) are often detected in luminal gastrointestinal cancers. We investigated regulation of ribosomal protein S6 kinase B1 (RPS6KB1) by AURKA and… read more here.
Keywords: gastrointestinal cancer; proliferation survival; aurka; cancer ... See more keywords
Hyperphosphorylation of RPS6KB1, rather than overexpression, predicts worse prognosis in non-small cell lung cancer patients
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DOI: 10.1371/journal.pone.0182891
Abstract: RPS6KB1 is the kinase of ribosomal protein S6 which is 70 kDa and is required for protein translation. Although the abnormal activation of RPS6KB1 has been found in types of diseases, its role and clinical… read more here.
Keywords: nsclc; rps6kb1; cell lung; non small ... See more keywords