Rhodospirillum rubruml-asparaginase targets tumor growth by a dual mechanism involving telomerase inhibition.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.08.078
Abstract: Rhodospirillum rubruml-asparaginase mutant RrA E149R, V150P, F151T (RrA) was previously identified to down-regulate telomerase activity along with catalyzing the hydrolysis of l-asparagine. The aim of this study was to define the effect of prolonged RrA… read more here.
Keywords: rra; telomerase; telomerase activity; inhibition ... See more keywords
Radioiodine remnant ablation in stage I adult papillary thyroid carcinoma: does it improve postoperative outcome?
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DOI: 10.1530/etj-22-0084
Abstract: Objective To determine whether radioiodine remnant ablation (RRA) reduces cause-specific mortality (CSM) or tumor recurrence rates (TRR) after potentially curative bilateral thyroidectomy (BT) in low-risk adult papillary thyroid carcinoma (APTC) patients, we compared postoperative outcomes… read more here.
Keywords: radioiodine remnant; thyroid; adult papillary; rra ... See more keywords
TSH ≥30 mU/l may not be necessary for successful 131I remnant ablation in patients with differentiated thyroid cancer.
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DOI: 10.1530/etj-22-0219
Abstract: BACKGROUND Purpose To determine whether thyroid stimulating hormone level ≥30 mU/l is necessary for radioiodine (131I) remnant ablation (RRA) in patients with differentiated thyroid cancer (DTC), as well as its influencing factors and predictors. METHODS… read more here.
Keywords: patients differentiated; differentiated thyroid; rra; remnant ablation ... See more keywords
Improvement of Biocatalytic Properties and Cytotoxic Activity of L-Asparaginase from Rhodospirillum rubrum by Conjugation with Chitosan-Based Cationic Polyelectrolytes
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DOI: 10.3390/ph15040406
Abstract: L-asparaginases (L-ASNases, EC 3.5.1.1) are a family of enzymes that are widely used for the treatment of lymphoblastic leukemias. L-ASNase from Rhodospirillum rubrum (RrA) has a low molecular weight, low glutaminase activity, and low immunogenicity,… read more here.
Keywords: rhodospirillum rubrum; cytotoxic activity; rra; activity ... See more keywords