A comprehensive evaluation of alignment software for reduced representation bisulfite sequencing data
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DOI: 10.1093/bioinformatics/bty174
Abstract: Motivation The rapid development of next-generation sequencing technology provides an opportunity to study genome-wide DNA methylation at single-base resolution. However, depletion of unmethylated cytosines brings challenges for aligning bisulfite-converted sequencing reads to a large reference.… read more here.
Keywords: methylation; cpg sites; reduced representation; rrbssim ... See more keywords