Proteome-Level Analysis Indicates Global Mechanisms for Post-Translational Regulation of RRM Domains.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2017.11.001
Abstract: RRM, or RNA-recognition motif, domains are the largest class of single-stranded RNA binding domains in the human proteome and play important roles in RNA processing, splicing, export, stability, packaging, and degradation. Using a current database… read more here.
Keywords: rrm; post translational; rrm domain; rrm domains ... See more keywords
ATP binds and inhibits the neurodegeneration-associated fibrillization of the FUS RRM domain
Sign Up to like & getrecommendations! Published in 2019 at "Communications Biology"
DOI: 10.1038/s42003-019-0463-x
Abstract: Adenosine triphosphate (ATP) provides energy for cellular processes but has recently been found to act also as a hydrotrope to maintain protein homeostasis. ATP bivalently binds the disordered domain of FUS containing the RG/RGG sequence… read more here.
Keywords: neurodegeneration associated; fus; rrm domain; fibrillization ... See more keywords