ATP is a cryptic binder of TDP-43 RRM domains to enhance stability and inhibit ALS/AD-associated fibrillation.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.11.088
Abstract: ATP is the universal energy currency for all cells but has cellular concentrations of 2-12 mM, much higher than required for its classic functions. RNA-recognition motif (RRM) constitutes one of the most abundant domains in eukaryotes… read more here.
Keywords: tdp rrm; fibrillation; als associated; rrm ... See more keywords
Proteome-Level Analysis Indicates Global Mechanisms for Post-Translational Regulation of RRM Domains.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2017.11.001
Abstract: RRM, or RNA-recognition motif, domains are the largest class of single-stranded RNA binding domains in the human proteome and play important roles in RNA processing, splicing, export, stability, packaging, and degradation. Using a current database… read more here.
Keywords: rrm; post translational; rrm domain; rrm domains ... See more keywords