Identification of lncRNA NEAT1/miR‐21/RRM2 axis as a novel biomarker in breast cancer
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.29225
Abstract: As a major disease that threatens the health of women worldwide, breast cancer (BC) lacks effective molecular markers in the clinic at the same time. We aim at finding a new biomarker of BC. In… read more here.
Keywords: neat1 mir; rrm2; breast cancer; mir rrm2 ... See more keywords
RRM2 Is a Putative Biomarker and Promotes Bladder Cancer Progression via PI3K/AKT/mTOR Pathway
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.31501
Abstract: Bladder cancer (BLCA) is the tenth most common cancer worldwide, characterized by its high recurrence and progression rates. Thus, identifying prognostic biomarkers and understanding its underlying mechanisms are imperative to enhance patient outcomes. In this… read more here.
Keywords: cancer; akt mtor; progression; rrm2 ... See more keywords
RRM2 enhances MYCN-driven neuroblastoma formation and acts as a synergistic target with CHK1 inhibition
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abn1382
Abstract: High-risk neuroblastoma, a pediatric tumor originating from the sympathetic nervous system, has a low mutation load but highly recurrent somatic DNA copy number variants. Previously, segmental gains and/or amplifications allowed identification of drivers for neuroblastoma… read more here.
Keywords: inhibition; chk1 inhibition; rrm2; formation ... See more keywords
Abstract 2407: Targeting ribonucleotide reductase subunit 2 (RRM2) to radio-sensitize glioblastoma
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-2407
Abstract: Purpose: Despite aggressive multimodality treatments, the median survival of glioblastoma (GBM) remains within the range of 12-15 months after diagnosis with standard-of-care surgery, radiation therapy (RT) and temozolomide (TMZ). Resistance frequently arises, exacerbating the clinical… read more here.
Keywords: inhibition; rrm2; expression; ribonucleotide reductase ... See more keywords
Abstract 3933: RRM2 inhibition by COH29 is a potential therapeutic strategy for atypical teratoid rhabdoid tumors
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-3933
Abstract: Introduction: Atypical teratoid rhabdoid tumors (ATRT) are a rare but aggressive malignancy in central nervous system, commonly occurring in early childhood. ATRT patients face a dismal prognosis despite aggressive therapy. Development of both effective and… read more here.
Keywords: rrm2; atrt; teratoid rhabdoid; atypical teratoid ... See more keywords
Translational evidence for RRM2 as a prognostic biomarker and therapeutic target in Ewing sarcoma
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Cancer"
DOI: 10.1186/s12943-021-01393-9
Abstract: © The Author(s) 2021. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you… read more here.
Keywords: article; rrm2; creative commons; licence ... See more keywords
Integration of scRNA-seq and ST-seq identifies hyperproliferative RRM2+ cells features and therapeutic targets in gastric cancer
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Translational Medicine"
DOI: 10.1186/s12967-025-06847-y
Abstract: Despite substantial progress in discovering novel therapeutic targets and compounds, cancer hyperproliferative cells (CHCs) play a central role in driving tumor progression in gastric cancer (GC). High-resolution single-cell RNA sequencing (scRNA-seq) integrated with spatial transcriptomics… read more here.
Keywords: therapeutic targets; cancer; gastric cancer; rrm2 ... See more keywords
A comprehensive analysis of ribonucleotide reductase subunit M2 for carcinogenesis in pan-cancer
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DOI: 10.1371/journal.pone.0299949
Abstract: Background Although there is evidence that ribonucleotide reductase subunit M2 (RRM2) is associated with numerous cancers, pan-cancer analysis has seldom been conducted. This study aimed to explore the potential carcinogenesis of RRM2 in pan-cancer using… read more here.
Keywords: cancer; ribonucleotide reductase; carcinogenesis; reductase subunit ... See more keywords
High expression of RRM2 as an independent predictive factor of poor prognosis in patients with lung adenocarcinoma.
Sign Up to like & getrecommendations! Published in 2020 at "Aging"
DOI: 10.18632/aging.202292
Abstract: Ribonucleotide reductase subunit M2 may play a role as a potential prognostic biomarker in several cancers. In this study, we evaluated whether RRM2 gene expression is associated with the prognosis of patients with lung adenocarcinoma… read more here.
Keywords: rrm2; prognosis; rrm2 expression; expression ... See more keywords
P53 suppresses ribonucleotide reductase via inhibiting mTORC1
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.17440
Abstract: Balanced deoxyribonucleotides pools are essential for cell survival and genome stability. Ribonucleotide reductase is the rate-limiting enzyme for the production of deoxyribonucleotides. We report here that p53 suppresses ribonucleotide reductase subunit 1 (RRM1) and 2… read more here.
Keywords: p53; rrm2; ribonucleotide reductase; rrm1 rrm2 ... See more keywords
High RRM2 Correlates with Mitochondrial and Immune Responses in the Eosinophilic Subtype of Clear Cell Renal Cell Carcinoma
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Inflammation Research"
DOI: 10.2147/jir.s478993
Abstract: Background Clear cell renal cell carcinoma (ccRCC), the predominant subtype of RCC, is distinguished by unique biological characteristics and heterogeneity, including eosinophilic and clear subtypes. Notwithstanding progress in therapy, immune checkpoint inhibitors (ICIs), and tyrosine… read more here.
Keywords: renal cell; cell; rrm2; eosinophilic subtype ... See more keywords