Identification of lncRNA NEAT1/miR‐21/RRM2 axis as a novel biomarker in breast cancer
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.29225
Abstract: As a major disease that threatens the health of women worldwide, breast cancer (BC) lacks effective molecular markers in the clinic at the same time. We aim at finding a new biomarker of BC. In… read more here.
Keywords: neat1 mir; rrm2; breast cancer; mir rrm2 ... See more keywords
RRM2 enhances MYCN-driven neuroblastoma formation and acts as a synergistic target with CHK1 inhibition
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abn1382
Abstract: High-risk neuroblastoma, a pediatric tumor originating from the sympathetic nervous system, has a low mutation load but highly recurrent somatic DNA copy number variants. Previously, segmental gains and/or amplifications allowed identification of drivers for neuroblastoma… read more here.
Keywords: inhibition; chk1 inhibition; rrm2; formation ... See more keywords
Abstract 2407: Targeting ribonucleotide reductase subunit 2 (RRM2) to radio-sensitize glioblastoma
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-2407
Abstract: Purpose: Despite aggressive multimodality treatments, the median survival of glioblastoma (GBM) remains within the range of 12-15 months after diagnosis with standard-of-care surgery, radiation therapy (RT) and temozolomide (TMZ). Resistance frequently arises, exacerbating the clinical… read more here.
Keywords: inhibition; rrm2; expression; ribonucleotide reductase ... See more keywords
Abstract 3933: RRM2 inhibition by COH29 is a potential therapeutic strategy for atypical teratoid rhabdoid tumors
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-3933
Abstract: Introduction: Atypical teratoid rhabdoid tumors (ATRT) are a rare but aggressive malignancy in central nervous system, commonly occurring in early childhood. ATRT patients face a dismal prognosis despite aggressive therapy. Development of both effective and… read more here.
Keywords: rrm2; atrt; teratoid rhabdoid; atypical teratoid ... See more keywords
Translational evidence for RRM2 as a prognostic biomarker and therapeutic target in Ewing sarcoma
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Cancer"
DOI: 10.1186/s12943-021-01393-9
Abstract: © The Author(s) 2021. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you… read more here.
Keywords: article; rrm2; creative commons; licence ... See more keywords
High expression of RRM2 as an independent predictive factor of poor prognosis in patients with lung adenocarcinoma.
Sign Up to like & getrecommendations! Published in 2020 at "Aging"
DOI: 10.18632/aging.202292
Abstract: Ribonucleotide reductase subunit M2 may play a role as a potential prognostic biomarker in several cancers. In this study, we evaluated whether RRM2 gene expression is associated with the prognosis of patients with lung adenocarcinoma… read more here.
Keywords: rrm2; prognosis; rrm2 expression; expression ... See more keywords
P53 suppresses ribonucleotide reductase via inhibiting mTORC1
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.17440
Abstract: Balanced deoxyribonucleotides pools are essential for cell survival and genome stability. Ribonucleotide reductase is the rate-limiting enzyme for the production of deoxyribonucleotides. We report here that p53 suppresses ribonucleotide reductase subunit 1 (RRM1) and 2… read more here.
Keywords: p53; rrm2; ribonucleotide reductase; rrm1 rrm2 ... See more keywords
Ribonucleotide reductase subunit M2 as a novel target for clear-cell renal cell carcinoma
Sign Up to like & getrecommendations! Published in 2019 at "OncoTargets and therapy"
DOI: 10.2147/ott.s196347
Abstract: Background: Sufficient supply of deoxyribonucleoside triphosphates (dNTPs) is required for the uncontrolled replication of cancers. The current study aimed to investigate the biological and clinical role of ribonucleotide reductase subunit M2 (RRM2), a key enzyme… read more here.
Keywords: renal cell; cell carcinoma; rrm2; cell ... See more keywords
LncRNA TTN-AS1 Regulates miR-524-5p and RRM2 to Promote Breast Cancer Progression
Sign Up to like & getrecommendations! Published in 2020 at "OncoTargets and therapy"
DOI: 10.2147/ott.s243482
Abstract: Background Recent studies suggest many long non-coding RNAs (lncRNAs) are crucial oncogenes or tumor suppressors. This study intended to investigate the biological function and mechanism of lncRNA TTN antisense RNA 1 (TTN-AS1) in the progression… read more here.
Keywords: expression; mir 524; rrm2; ttn ... See more keywords
Cancer Fighting SiRNA-RRM2 loaded nanorobots.
Sign Up to like & getrecommendations! Published in 2020 at "Pharmaceutical nanotechnology"
DOI: 10.2174/2211738508666200128120142
Abstract: BACKGROUND Silencing of several genes are critical for cancer therapy. These genes may be apoptotic gene, cell proliferation gene, DNA synthesis gene etc. Ribonucleotide Reductase (RR) two subunit RRM1 and RRM2 are critical for DNA… read more here.
Keywords: rrm2; cancer therapy; cancer; progression ... See more keywords
High expression of RRM2 mediated by non-coding RNAs correlates with poor prognosis and tumor immune infiltration of hepatocellular carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Medicine"
DOI: 10.3389/fmed.2022.833301
Abstract: Hepatocellular carcinoma (HCC) is known to have a poor prognosis. Accumulating evidence indicates that RRM2 plays a critical role in the occurrence and progression of multiple human cancers. However, the knowledge about RRM2 in HCC… read more here.
Keywords: infiltration; rrm2; hcc; expression ... See more keywords