Clinical Efficacy of Intracellular Molecular Inhibitors for Relapsed, Refractory Multiple Myeloma: A Systematic Review of Early Clinical Data
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DOI: 10.1182/blood-2018-99-111587
Abstract: Introduction: Intracellular molecular inhibitors act by inducing apoptosis due to inhibition of intracellular proteins like 20S proteasome subunit, histone deacetylases (HDAC's), exportin 1 (XPO1), cyclin-dependent kinases (CDKs) and kinesin spindle protein (KSP). These proteins are… read more here.
Keywords: combination; rrmm patients; patients phase; intracellular molecular ... See more keywords
Use of Anti-Infective Prophylaxis in Newly Diagnosed and Relapsed/Refractory Multiple Myeloma Patients Initiating Treatment with Daratumumab
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DOI: 10.1182/blood-2020-134086
Abstract: Introduction: Infections continue to be one of the main causes of morbidity and mortality in multiple myeloma (MM) patients. Compared to the general population, MM patients have a 7-fold increased risk of bacterial infections and… read more here.
Keywords: ndmm rrmm; rrmm patients; anti infective; infective prophylaxis ... See more keywords
Meta-analysis of the efficacy of treatments for newly diagnosed and relapsed/refractory multiple myeloma with del(17p).
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DOI: 10.18632/oncotarget.18722
Abstract: We analyzed the treatment of newly diagnosed and relapsed/refractory multiple myeloma (NDMM/RRMM) patients with del(17p). Thirteen prospective studies that evaluated 3,187 MM patients, including 685with del(17p), were included in our meta-analysis. The incidence of del(17p)… read more here.
Keywords: del 17p; newly diagnosed; rrmm patients; dexamethasone ... See more keywords
Optimizing therapy for del(17p) multiple myeloma
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DOI: 10.18632/oncotarget.22987
Abstract: We read with interest the publication by Liu et al. reporting the results from a meta‐analysis of 13 prospective studies evaluating the efficacy of proteasome inhibitor/immunomodulatory drug‐based treatments for newly diagnosed (ND) and relapsed/ refractory… read more here.
Keywords: del; pfs; del 17p; rrmm patients ... See more keywords