Identification of Potential Biomarkers in the Peripheral Blood Mononuclear Cells of Relapsing-Remitting Multiple Sclerosis Patients.
Sign Up to like & getrecommendations! Published in 2022 at "Inflammation"
DOI: 10.1007/s10753-022-01662-9
Abstract: Multiple sclerosis (MS) is described as an immune disorder with inflammation and neurodegeneration. Relapsing-remitting MS (RRMS) is one of the most common types of MS. The diagnostic manner for this disorder typically includes the usage of magnetic resonance… read more here.
Keywords: peripheral blood; relapsing remitting; blood mononuclear; rrms patients ... See more keywords
Untreated relapsing remitting multiple sclerosis patients show antibody production against latent Epstein Barr Virus (EBV) antigens mainly in the periphery and innate immune IL-8 responses preferentially in the CNS
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Neuroimmunology"
DOI: 10.1016/j.jneuroim.2017.02.017
Abstract: BACKGROUND Multiple sclerosis (MS) is an inflammatory and neurodegenerative disorder of the central nervous system (CNS). Reliable biomarkers are urgently needed for its diagnosis and management, and as clues to its pathogenesis, in which EBV… read more here.
Keywords: innate; anti ebna; igg; multiple sclerosis ... See more keywords
Application of definitions for conversion to secondary progressive MS in a Danish nationwide population.
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DOI: 10.1016/j.msard.2021.103319
Abstract: BACKGROUND The number of patients with relapsing remitting multiple sclerosis (RRMS) who convert to secondary progressive (SP) MS is uncertain, and with emerging treatment options for SPMS, it is important to identify RRMS patients in… read more here.
Keywords: spms; secondary progressive; disease modifying; multiple sclerosis ... See more keywords
Cytotoxic B Cells in Relapsing-Remitting Multiple Sclerosis Patients
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DOI: 10.3389/fimmu.2022.750660
Abstract: Background Emerging evidence of antibody-independent functions, as well as the clinical efficacy of anti-CD20 depleting therapies, helped to reassess the contribution of B cells during multiple sclerosis (MS) pathogenesis. Objective To investigate whether CD19+ B… read more here.
Keywords: gzmb; relapsing remitting; cd8 lymphocytes; rrms patients ... See more keywords
Immunological Subsets Characterization in Newly Diagnosed Relapsing–Remitting Multiple Sclerosis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.819136
Abstract: Objectives Using flow cytometry, we characterized myeloid, B, and T cells in patients recently diagnosed with relapsing–remitting multiple sclerosis (RRMS) naive to disease-modifying therapies (DMTs). Methods This prospective case–control study was conducted in the tertiary… read more here.
Keywords: relapsing remitting; diagnosed relapsing; remitting multiple; multiple sclerosis ... See more keywords
Low Memory T Cells Blood Counts and High Naïve Regulatory T Cells Percentage at Relapsing Remitting Multiple Sclerosis Diagnosis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.901165
Abstract: Objective To assess the peripheral immune system of newly diagnosed relapsing remitting multiple sclerosis (RRMS) patients and compare it to healthy controls (HC). Methods Cross-sectional study with 30 treatment-naïve newly diagnosed RRMS patients, and 33… read more here.
Keywords: blood counts; memory; blood; memory cells ... See more keywords
Altered Functional Connectivity of Striatal Subregions in Patients with Multiple Sclerosis
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DOI: 10.3389/fneur.2017.00129
Abstract: Abnormal corticostriatal resting-state functional connectivity (rsFC) has been implicated in the neuropathology of multiple sclerosis. The striatum, a component of the basal ganglia, is involved in diverse functions including movement, cognition, emotion, and limbic information… read more here.
Keywords: striatal subregions; connectivity; multiple sclerosis; rrms patients ... See more keywords
MRI-Based Brain Volumetry at a Single Time Point Complements Clinical Evaluation of Patients With Multiple Sclerosis in an Outpatient Setting
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DOI: 10.3389/fneur.2018.00545
Abstract: Purpose: Thalamic atrophy and whole brain atrophy in multiple sclerosis (MS) are associated with disease progression. The motivation of this study was to propose and evaluate a new grouping scheme which is based on MS… read more here.
Keywords: single time; atrophy; brain; rrms patients ... See more keywords
Descriptive Analysis of Real-World Data on Fingolimod Long-Term Treatment of Young Adult RRMS Patients
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DOI: 10.3389/fneur.2021.637107
Abstract: Background: Fingolimod (Gilenya®) is approved for adult and pediatric patients with highly active relapsing–remitting multiple sclerosis (RRMS). Objectives: The objective was to describe the effectiveness of fingolimod in young adults compared to older patients in… read more here.
Keywords: real world; term; long term; term treatment ... See more keywords
Diffusion Tensor Imaging Revealed Microstructural Changes in Normal-Appearing White Matter Regions in Relapsing–Remitting Multiple Sclerosis
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DOI: 10.3389/fnins.2022.837452
Abstract: Background Axons and myelin sheaths are the physical foundation for white matter (WM) to perform normal functions. Our previous study found the metabolite abnormalities in frontal, parietal, and occipital normal-appearing white matter (NAWM) regions in… read more here.
Keywords: corona radiata; white matter; tensor imaging; diffusion tensor ... See more keywords