tRNA Maturation Defects Lead to Inhibition of rRNA Processing via Synthesis of pppGpp.
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DOI: 10.1016/j.molcel.2019.03.030
Abstract: rRNAs and tRNAs universally require processing from longer primary transcripts to become functional for translation. Here, we describe an unsuspected link between tRNA maturation and the 3' processing of 16S rRNA, a key step in… read more here.
Keywords: maturation; maturation defects; rrna processing; trna maturation ... See more keywords
Early rRNA processing is a stress-dependent regulatory event whose inhibition maintains nucleolar integrity
Sign Up to like & getrecommendations! Published in 2021 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkab1231
Abstract: Abstract The production of ribosomes is an energy-intensive process owing to the intricacy of these massive macromolecular machines. Each human ribosome contains 80 ribosomal proteins and four non-coding RNAs. Accurate assembly requires precise regulation of… read more here.
Keywords: response; stress; inhibition; rrna processing ... See more keywords
The ubiquitin-specific protease USP36 SUMOylates EXOSC10 and promotes the nucleolar RNA exosome function in rRNA processing
Sign Up to like & getrecommendations! Published in 2023 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkad140
Abstract: Abstract The RNA exosome is an essential 3′ to 5′ exoribonuclease complex that mediates degradation, processing and quality control of virtually all eukaryotic RNAs. The nucleolar RNA exosome, consisting of a nine-subunit core and a… read more here.
Keywords: specific protease; protease usp36; ubiquitin specific; rna exosome ... See more keywords
Plant-specific ribosome biogenesis factors in Arabidopsis thaliana with essential function in rRNA processing
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DOI: 10.1093/nar/gky1261
Abstract: Abstract rRNA processing and assembly of ribosomal proteins during maturation of ribosomes involve many ribosome biogenesis factors (RBFs). Recent studies identified differences in the set of RBFs in humans and yeast, and the existence of… read more here.
Keywords: plant; rrna; rrna processing; plant specific ... See more keywords
PALE-GREEN LEAF12 Encodes a Novel Pentatricopeptide Repeat Protein Required for Chloroplast Development and 16S rRNA Processing in Rice
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DOI: 10.1093/pcp/pcy229
Abstract: Pentatricopeptide repeat (PPR) proteins regulate organellar gene expression in plants, through their involvement in organellar RNA metabolism. In rice (Oryza sativa), 477 genes are predicted to encode PPR proteins; however, the majority of their functions… read more here.
Keywords: protein; rice; chloroplast development; 16s rrna ... See more keywords