Autophagy regulates rRNA synthesis
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DOI: 10.1080/19491034.2022.2114661
Abstract: ABSTRACT Autophagy has emerged as a key regulator of cell metabolism. Recently, we have demonstrated that autophagy is involved in RNA metabolism by regulating ribosomal RNA (rRNA) synthesis. We found that autophagy-deficient cells display much… read more here.
Keywords: rna polymerase; rrna synthesis; synthesis; autophagy ... See more keywords
LYAR potentiates rRNA synthesis by recruiting BRD2/4 and the MYST-type acetyltransferase KAT7 to rDNA
Sign Up to like & getrecommendations! Published in 2019 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkz747
Abstract: Abstract Activation of ribosomal RNA (rRNA) synthesis is pivotal during cell growth and proliferation, but its aberrant upregulation may promote tumorigenesis. Here, we demonstrate that the candidate oncoprotein, LYAR, enhances ribosomal DNA (rDNA) transcription. Our… read more here.
Keywords: lyar; rrna synthesis; rdna; kat7 ... See more keywords
ECT2-Dependent rRNA Synthesis Is Critical for Lung Cancer Oncogenesis.
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DOI: 10.1158/2159-8290.cd-rw2017-025
Abstract: ECT2 mediates Kras-Trp53-driven lung adenocarcinoma initiation and transformed growth. read more here.
Keywords: dependent rrna; rrna synthesis; lung; cancer ... See more keywords