Activity dependent LoNA regulates translation by coordinating rRNA transcription and methylation
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DOI: 10.1038/s41467-018-04072-4
Abstract: The ribosome is indispensable for precisely controlling the capacity of protein synthesis. However, how translational machinery is coordinated to meet the translational demands remains elusive. Here, we identify a nucleolar-specific lncRNA (LoNA), its 5′ portion… read more here.
Keywords: methylation; rrna transcription; lona; activity ... See more keywords
Human pre-60S assembly factors link rRNA transcription to pre-rRNA processing
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DOI: 10.1101/2022.03.01.482553
Abstract: In eukaryotes, the nucleolus is the site of ribosome biosynthesis, an essential process in all cells. While human ribosome assembly is largely evolutionarily conserved, many of the regulatory details underlying its control and function have… read more here.
Keywords: rrna transcription; transcription; pebow complex; pre ... See more keywords