The Idiopathic Pulmonary Fibrosis-Associated Single Nucleotide Polymorphism RS35705950 Is Transcribed in a MUC5B Promoter Associated Long Non-Coding RNA (AC061979.1)
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DOI: 10.1101/2022.01.18.476727
Abstract: LncRNAs are involved in regulatory processes in the human genome, including gene expression. The rs35705950 SNP, previously associated with IPF, overlaps the recently annotated lncRNA AC061979.1, a 1,712 nucleotide transcript located within the MUC5B promoter… read more here.
Keywords: non coding; expression; muc5b promoter; rs35705950 ... See more keywords
MUC5B promoter variant rs35705950, rare but significant susceptibility locus in rheumatoid arthritis-interstitial lung disease with usual interstitial pneumonia in Asian populations
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DOI: 10.1136/rmdopen-2022-002790
Abstract: Background MUC5B variant rs35705950 is the common and most significant risk variant for rheumatoid arthritis-interstitial lung disease (RA-ILD) in Western populations. However, little is known about its significant association with RA-ILD in Asian populations. We… read more here.
Keywords: variant rs35705950; rheumatoid arthritis; lung disease; interstitial lung ... See more keywords
A MUC5B Gene Polymorphism, rs35705950-T, Confers Protective Effects Against COVID-19 Hospitalization but Not Severe Disease or Mortality
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DOI: 10.1164/rccm.202109-2166oc
Abstract: Rationale A common MUC5B gene polymorphism, rs35705950-T, is associated with idiopathic pulmonary fibrosis (IPF), but its role in severe acute respiratory syndrome coronavirus 2 infection and disease severity is unclear. Objectives To assess whether rs35705950-T… read more here.
Keywords: muc5b gene; disease; polymorphism rs35705950; meta ... See more keywords
COVID-19 Survivor Patients Carrying the Rs35705950 Risk Allele in MUC5B Have Higher Plasma Levels of Mucin 5B
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DOI: 10.3390/cimb44080226
Abstract: Background: Genetic susceptibility to infectious diseases is partly due to the variation in the human genome, and COVID-19 is not the exception. This study aimed to identify whether risk alleles of known genes linked with… read more here.
Keywords: risk allele; levels mucin; plasma; risk ... See more keywords