LAUSR

The CREBRF diabetes-protective rs373863828-A allele is associated with enhanced early insulin release in men of Māori and Pacific ancestry

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0 Published in 2021 at "Diabetologia"

DOI: 10.1007/s00125-021-05552-x

Abstract: The minor A allele of rs373863828 (CREBRF p.Arg457Gln) is associated with increased BMI, but reduced risk of type 2 and gestational diabetes in Polynesian (Pacific peoples and Aotearoa New Zealand Māori) populations. This study investigates… read more here.

Keywords: insulin; rs373863828; insulin release; ancestry ... See more keywords

The minor allele of the CREBRF rs373863828 p.R457Q coding variant is associated with reduced levels of myostatin in males: Implications for body composition

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3 Published in 2022 at "Molecular Metabolism"

DOI: 10.1016/j.molmet.2022.101464

Abstract: Objective The minor allele (A) of the rs373863828 variant (p.Arg457Gln) in CREBRF is restricted to indigenous peoples of the Pacific islands (including New Zealand Māori and peoples of Polynesia), with a frequency of up to… read more here.

Keywords: levels myostatin; mass; rs373863828; allele ... See more keywords

Widespread prevalence of a CREBRF variant amongst Māori and Pacific children is associated with weight and height in early childhood

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1 Published in 2018 at "International Journal of Obesity"

DOI: 10.1038/ijo.2017.230

Abstract: Objective:Investigating a large and ethnically diverse cohort from the Pacific region, we aimed to replicate and extend the recently reported findings that a CREBRF genetic variant is strongly associated with body mass index in Samoans.Methods:A… read more here.

Keywords: rs373863828; variant; ori pacific; crebrf variant ... See more keywords

A missense variant, rs373863828-A (p.Arg457Gln), of CREBRF and body mass index in Oceanic populations

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1 Published in 2017 at "Journal of Human Genetics"

DOI: 10.1038/jhg.2017.44

Abstract: It has been suggested that a ‘thrifty’ genotype hypothesis can account for high prevalence of obesity in the island populations of Oceania. A recent genome-wide association study revealed that a missense variant, rs373863828-A (p.Arg457Gln), of… read more here.

Keywords: crebrf; rs373863828; variant rs373863828; arg457gln crebrf ... See more keywords