PNPLA3 rs738409 and risk of fibrosis in NAFLD: Exploring mediation pathways through intermediate histological features
Sign Up to like & getrecommendations! Published in 2022 at "Hepatology"
DOI: 10.1002/hep.32491
Abstract: It is unclear whether rs738409 (p.I148M) missense variant in patatin‐like phospholipase domain‐containing 3 rs738409 promotes fibrosis development by triggering specific fibrogenic pathways or by creating an unfavorable microenvironment by promoting steatosis, inflammation, and ultimately fibrosis.… read more here.
Keywords: pnpla3 rs738409; fibrosis nafld; rs738409 risk; risk fibrosis ... See more keywords
The risk of cirrhosis and its complications based on PNPLA3 rs738409 G allele frequency.
Sign Up to like & getrecommendations! Published in 2021 at "Digestive diseases"
DOI: 10.1159/000521062
Abstract: BACKGROUND Data regarding the influence of patatin-like phospholipase domain-containing 3 (PNPLA3) polymorphism for patients with liver cirrhosis (LC) are scarce. OBJECTIVE This study assesses the role of the PNPLA3 polymorphism for the development of LC… read more here.
Keywords: frequency; rs738409; pnpla3 polymorphism; cirrhosis ... See more keywords