Signal Peptidase-Mediated Cleavage of the Anti-σ Factor RsiP at Site 1 Controls σP Activation and β-Lactam Resistance in Bacillus thuringiensis
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DOI: 10.1128/mbio.03707-21
Abstract: β-Lactam antibiotics are important for the treatment of many bacterial infections. However, resistance mechanisms have become increasingly more prevalent. ABSTRACT In Bacillus thuringiensis, β-lactam antibiotic resistance is controlled by the extracytoplasmic function (ECF) σ factor… read more here.
Keywords: signal peptidase; cleavage; resistance; rsip ... See more keywords
Activation of the Extracytoplasmic Function σ Factor σP by β-Lactams in Bacillus thuringiensis Requires the Site-2 Protease RasP
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DOI: 10.1128/msphere.00511-19
Abstract: The discovery of antibiotics to treat bacterial infections has had a dramatic and positive impact on human health. However, shortly after the introduction of a new antibiotic, bacteria often develop resistance. The bacterial cell envelope… read more here.
Keywords: activation; thuringiensis; resistance; rsip ... See more keywords