RSK2 and its binding partners in cell proliferation, transformation and cancer development
Sign Up to like & getrecommendations! Published in 2017 at "Archives of Pharmacal Research"
DOI: 10.1007/s12272-016-0880-z
Abstract: RSK2 is a serine/threonine kinase and a member of the p90 ribosomal S6 kinase (p90RSK; RSKs) family, which regulates cell proliferation and transformation induced by tumor promoters such as epithelial growth factor (EGF), 12-O-tetradecanoylphorbol-13-acetate (TPA),… read more here.
Keywords: rsk2; cell proliferation; cancer development;
PDK1 promotes the inflammatory progress of fibroblast-like synoviocytes by phosphorylating RSK2.
Sign Up to like & getrecommendations! Published in 2017 at "Cellular immunology"
DOI: 10.1016/j.cellimm.2016.10.007
Abstract: This study investigated the role of PDK1 in inflammatory response which is initiated by TNF-α and analyzed the association between PDK1 and RSK2. TNF-α were added into MH7A cells to induce inflammation condition. Through overexpressing… read more here.
Keywords: mh7a cells; rsk2; pdk1; rsk2 pdk1 ... See more keywords
85 Enhanced nuclear RSK1 signalling promotes cardiac hypertrophy in mice in vivo, but compromises compensated hypertrophy induced by phenylephrine
Sign Up to like & getrecommendations! Published in 2018 at "Heart"
DOI: 10.1136/heartjnl-2018-bcs.85
Abstract: Background The α1-adrenergic receptor (α1AR) agonist phenylephrine (PE), acts via ERK1/2 to phosphorylate (i.e. activate) p90 ribosomal S6 kinases (RSKs). PE promotes compensated hypertrophy and increases cardiomyocyte size. ERK1/2 and RSKs phosphorylate transcription factors producing… read more here.
Keywords: rsk2; rsk1; hypertrophy; expression ... See more keywords
Molecular Targeting of ERKs/RSK2 Signaling in Cancers.
Sign Up to like & getrecommendations! Published in 2017 at "Current pharmaceutical design"
DOI: 10.2174/1381612823666170714142338
Abstract: Accumulating studies have provided concrete evidence that p90 ribosomal S6 kinase 2 (RSK2) is a key signaling molecule involved in cell proliferation, transformation, and cancer development. RSK2 is known to be an etiological gene of… read more here.
Keywords: molecular targeting; rsk2; targeting erks; rsk2 signaling ... See more keywords
The Rationale for the Dual-Targeting Therapy for RSK2 and AKT in Multiple Myeloma
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DOI: 10.3390/ijms23062919
Abstract: Multiple myeloma (MM) is characterized by remarkable cytogenetic/molecular heterogeneity among patients and intraclonal diversity even in a single patient. We previously demonstrated that PDPK1, the master kinase of series of AGC kinases, is universally active… read more here.
Keywords: rsk2 akt; rsk2; multiple myeloma; dual targeting ... See more keywords
Hepatitis B Virus X Protein Modulates p90 Ribosomal S6 Kinase 2 by ERK to Promote Growth of Hepatoma Cells
Sign Up to like & getrecommendations! Published in 2023 at "Viruses"
DOI: 10.3390/v15051182
Abstract: Hepatitis B virus (HBV) infection is a leading cause of hepatocellular carcinoma (HCC), one of the most prevalent malignant tumors worldwide that poses a significant threat to human health. The multifunctional regulator known as Hepatitis… read more here.
Keywords: ribosomal kinase; hcc; rsk2; hepatitis virus ... See more keywords