Baicalein inhibits RLS3-induced ferroptosis in melanocytes.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2021.05.010
Abstract: We explored the effect of baicalein on the ferroptosis of melanocytes in vitiligo. Melanocytes were treated with single RSL3 or combined RSL3 with FAC for 24 h and the effect of baicalein on RSL3 toxicity was… read more here.
Keywords: ferroptosis melanocytes; inhibits rls3; ferroptosis; baicalein inhibits ... See more keywords
RSL3 enhances the antitumor effect of cisplatin on prostate cancer cells via causing glycolysis dysfunction.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2021.114741
Abstract: The resistance to cisplatin (DDP) and dose-related toxicity are the two important obstacles in the chemotherapy of prostate cancer (PCa) patients. The present study demonstrated that cotreatment of DDP and RSL3, a type of small… read more here.
Keywords: glycolysis dysfunction; ddp; prostate cancer; rsl3 ... See more keywords
Chlorobenzoquinones Aggravate RSL3-Induced Ferroptosis in ROS-Dependent Manner.
Sign Up to like & getrecommendations! Published in 2024 at "Chemical research in toxicology"
DOI: 10.1021/acs.chemrestox.4c00100
Abstract: Chlorobenzoquinones (CBQs) are a class of emerging water disinfection byproducts that pose significant risks to public health. In this study, we found that three CBQs (tetrachloro-1,4-benzoquinone, 2,5-dichloro-1,4-benzoquinone, and 2-chloro-1,4-benzoquinone) can significantly aggravate cell death caused… read more here.
Keywords: rsl3; cbqs; chlorobenzoquinones aggravate; rsl3 induced ... See more keywords
Recharacterization of the Tumor Suppressive Mechanism of RSL3 Identifies the Selenoproteome as a Druggable Pathway in Colorectal Cancer.
Sign Up to like & getrecommendations! Published in 2025 at "Cancer research"
DOI: 10.1158/0008-5472.can-24-3478
Abstract: Ferroptosis is a non-apoptotic form of cell death driven by iron-dependent lipid peroxide accumulation. Colorectal cancer (CRC) cells feature elevated intracellular iron and reactive oxygen species (ROS) that heighten ferroptosis sensitivity. The ferroptosis inducer (S)-RSL3… read more here.
Keywords: colorectal cancer; cancer; rsl3; crc ... See more keywords
RSL3 Drives Ferroptosis Through GPX4 Inactivation and ROS Production in Colorectal Cancer
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2018.01371
Abstract: Ferroptosis is an iron-dependent, oxidative cell death, and is characterized by iron-dependent accumulation of reactive oxygen species (ROS) within the cell. It has been implicated in various human diseases, including cancer. Recently, ferroptosis, as a… read more here.
Keywords: ferroptosis; cell death; cancer; cell ... See more keywords
Novel (1S,3R)-RSL3-Encapsulated Polyunsaturated Fatty Acid Rich Liposomes Sensitise Multiple Myeloma Cells to Ferroptosis-Mediated Cell Death
Sign Up to like & getrecommendations! Published in 2025 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms26146579
Abstract: Multiple myeloma (MM) is an incurable malignancy of plasma cells that accounts for 10% of all haematological malignancies diagnosed worldwide. The poor outcome of patients with MM highlights the ongoing need for novel treatment strategies.… read more here.
Keywords: multiple myeloma; rsl3; ferroptosis; cell ... See more keywords
Selective Elimination of Genetic Variants of Human Embryonic Stem Cells from High Vulnerability to Ferroptosis
Sign Up to like & getrecommendations! Published in 2024 at "Biomaterials Research"
DOI: 10.34133/bmr.0093
Abstract: Despite the great promise of human pluripotent stem cell (hPSC)-based cell therapy, safety concerns arise from genetic aberrations during in vitro culture, due to their uncertain consequences. Notably, these genetic aberrations confer a survival trait… read more here.
Keywords: aberrant hpscs; rsl3; stem; culture ... See more keywords
Co-treatment with triptolide and RSL3 induces hepatocellular carcinoma cell apoptosis and ferroptosis
Sign Up to like & getrecommendations! Published in 2025 at "Molecular Medicine Reports"
DOI: 10.3892/mmr.2025.13567
Abstract: Glutathione peroxidase 4 (GPx4; also known as phospholipid hydroperoxide glutathione peroxidase) inhibits cell death, including apoptosis and ferroptosis, by reducing lipid peroxidation. In addition, western blot assays showed that GPx4 protein levels were elevated in… read more here.
Keywords: treatment; rsl3; apoptosis ferroptosis; hepatocellular carcinoma ... See more keywords