Non-equivalence of Wnt and R-spondin ligands during Lgr5+ intestinal stem cell self-renewal
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DOI: 10.1038/nature22313
Abstract: The canonical Wnt/β-catenin signalling pathway governs diverse developmental, homeostatic and pathological processes. Palmitoylated Wnt ligands engage cell-surface frizzled (FZD) receptors and LRP5 and LRP6 co-receptors, enabling β-catenin nuclear translocation and TCF/LEF-dependent gene transactivation. Mutations in… read more here.
Keywords: wnt; rspo ligands; stem cell; stem ... See more keywords