Preclinical evaluation of bacterially produced RSV-G protein vaccine: Strong protection against RSV challenge in cotton rat model
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep42428
Abstract: In current study, we evaluated the safety and protective efficacy of recombinant unglycosylated RSV G protein ectodomain produced in E. coli (in presence and absence of oil-in-water adjuvant) in a preclinical RSV susceptible cotton rat… read more here.
Keywords: protein; protein vaccine; rsv protein; cotton rat ... See more keywords
Respiratory Syncytial Virus: Targeting the G Protein Provides a New Approach for an Old Problem
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Virology"
DOI: 10.1128/jvi.01302-17
Abstract: ABSTRACT Respiratory syncytial virus (RSV) is a major cause of lower respiratory tract infection (LRTI) annually affecting >2 million children in the United States 65 years old), RSV results in ∼175,000 hospitalizations annually in the… read more here.
Keywords: rsv protein; rsv; syncytial virus; respiratory syncytial ... See more keywords
Structure-Based Design and Antigenic Validation of Respiratory Syncytial Virus G Immunogens
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DOI: 10.1128/jvi.02201-21
Abstract: Respiratory syncytial virus (RSV) causes severe lower respiratory diseases of children, the elderly, and immunocompromised populations. There currently are no FDA-approved RSV vaccines. ABSTRACT Respiratory syncytial virus (RSV) is a leading cause of severe lower… read more here.
Keywords: structure; rsv protein; rsv; respiratory syncytial ... See more keywords
RSV Replication, Transmission, and Disease Are Influenced by the RSV G Protein
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DOI: 10.3390/v14112396
Abstract: It is important to understand the features affecting virus replication, fitness, and transmissibility as they contribute to the outcome of infection and affect disease intervention approaches. Respiratory syncytial virus (RSV) is a major contributor to… read more here.
Keywords: rsv replication; disease; rsv protein; replication ... See more keywords