A safe and effective mucosal RSV vaccine in mice consisting of RSV phosphoprotein and flagellin variant.
Sign Up to like & getrecommendations! Published in 2021 at "Cell reports"
DOI: 10.1016/j.celrep.2021.109401
Abstract: Respiratory syncytial virus (RSV) is a major cause of serious acute lower respiratory tract infection in infants and the elderly. The lack of a licensed RSV vaccine calls for the development of vaccines with other… read more here.
Keywords: rsv vaccine; effective mucosal; flagellin variant; rsv phosphoprotein ... See more keywords
Respiratory syncytial virus vaccine: where are we now and what comes next?
Sign Up to like & getrecommendations! Published in 2018 at "Expert Opinion on Biological Therapy"
DOI: 10.1080/14712598.2018.1544239
Abstract: ABSTRACT Introduction: Respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract infection in infants and elderly and to date, there is no safe or effective vaccine against RSV. Areas Covered: This review… read more here.
Keywords: vaccine; syncytial virus; respiratory syncytial; rsv vaccine ... See more keywords
Immunopathogenesis associated with formaldehyde-inactivated RSV vaccine in preclinical and clinical studies
Sign Up to like & getrecommendations! Published in 2017 at "Expert Review of Vaccines"
DOI: 10.1080/14760584.2017.1260452
Abstract: ABSTRACT Introduction: Respiratory syncytial virus (RSV) infection is responsible for one-third of deaths of acute lower respiratory infection in children less than one-year-old. The formaldehyde-inactivated RSV vaccine trial conducted in the 1960s predisposed the vaccinees… read more here.
Keywords: rsv vaccines; rsv vaccine; inactivated rsv; rsv ... See more keywords
Building a better RSV vaccine
Sign Up to like & getrecommendations! Published in 2019 at "Science"
DOI: 10.1126/science.365.6452.458-p
Abstract: Vaccines Respiratory syncytial virus (RSV) causes severe respiratory disease, especially in infants and the elderly. However, attempts to produce effective human vaccines have largely been unsuccessful. Structure-based design has been used to generate an RSV… read more here.
Keywords: biology; rsv; rsv vaccine; building better ... See more keywords
Determining Immune and miRNA Biomarkers Related to Respiratory Syncytial Virus (RSV) Vaccine Types
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2019.02323
Abstract: Respiratory Syncytial Virus (RSV) causes serious respiratory tract illness and substantial morbidity and some mortality in populations at the extremes of age, i.e., infants, young children, and the elderly. To date, RSV vaccine development has… read more here.
Keywords: virus rsv; respiratory syncytial; rsv vaccine; syncytial virus ... See more keywords
A Recombinant MVA-Based RSV Vaccine Induces T-Cell and Antibody Responses That Cooperate in the Protection Against RSV Infection
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.841471
Abstract: Respiratory syncytial virus (RSV) causes a respiratory disease with a potentially fatal outcome especially in infants and elderly individuals. Several vaccines failed in pivotal clinical trials, and to date, no vaccine against RSV has been… read more here.
Keywords: rsv vaccine; rsv; mva; vaccine ... See more keywords
An Optimized FI-RSV Vaccine Effectively Protects Cotton Rats and BALB/c Mice without Causing Enhanced Respiratory Disease
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DOI: 10.3390/v14102085
Abstract: Background: Despite considerable efforts toward vaccine development in past decades, no effective vaccines against respiratory syncytial virus (RSV) are available. Recently, we showed that an optimized formalin concentration can preserve prefusion protein (pre-F) on RSV-infected… read more here.
Keywords: opti rsv; rsv vaccine; causing enhanced; rsv ... See more keywords