High-throughput mapping of RNA solvent accessibility at the single-nucleotide resolution by RtcB ligation between a fixed 5′-OH-end linker and unique 3′-P-end fragments from hydroxyl radical cleavage
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DOI: 10.1080/15476286.2022.2145098
Abstract: ABSTRACT Given the challenges for the experimental determination of RNA tertiary structures, probing solvent accessibility has become increasingly important to gain functional insights. Among various chemical probes developed, backbone-cleaving hydroxyl radical is the only one… read more here.
Keywords: hydroxyl radical; rtcb ligation; ligation fixed; end ... See more keywords