Differential accumulation of tau pathology between reciprocal F1 hybrids of rTg4510 mice
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DOI: 10.1038/s41598-021-89142-2
Abstract: Tau, a family of microtubule-associated proteins, forms abnormal intracellular inclusions, so-called tau pathology, in a range of neurodegenerative diseases collectively known as tauopathies. The rTg4510 mouse model is a well-characterized bitransgenic F1 hybrid mouse model… read more here.
Keywords: tau; tau pathology; pathology; accumulation tau ... See more keywords
Differences in Synaptic Dysfunction Between rTg4510 and APP/PS1 Mouse Models of Alzheimer’s Disease
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DOI: 10.3233/jad-170457
Abstract: Genetically modified mice have provided insights into the progression and pathology of Alzheimer’s disease (AD). Here, we have examined two mouse models of AD: the rTg4510 mouse, which overexpresses mutant human Tau gene, and the… read more here.
Keywords: ps1; pathology; rtg4510; mice ... See more keywords
Altered Brain Metabolome Is Associated with Memory Impairment in the rTg4510 Mouse Model of Tauopathy
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DOI: 10.3390/metabo10020069
Abstract: Alzheimer’s disease (AD) is characterized, amongst other features, by the pathologic accumulation of abnormally phosphorylated tau filaments in neurons that lead to neurofibrillary tangles. However, the molecular mechanisms by which the abnormal processing of tau… read more here.
Keywords: memory impairment; rtg4510; impairment; altered brain ... See more keywords