Molecular alterations in Hürthle cell neoplasms of thyroid: A fine needle aspiration cytology study with cytology‐histology correlation
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Cytopathology"
DOI: 10.1002/cncy.22370
Abstract: Hürthle cell features are frequently observed on the fine‐needle aspiration (FNA) cytology of thyroid nodules and often pose a diagnostic challenge because of a significant overlap between cytomorphologic features seen in benign and malignant lesions.… read more here.
Keywords: needle aspiration; fine needle; cytology; rthle cell ... See more keywords
Hürthle cell‐predominant thyroid fine needle aspiration cytology: A four risk‐factor model highly accurate in excluding malignancy and predicting neoplasm
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DOI: 10.1002/dc.25000
Abstract: Interpretation of Hürthle cell‐predominant cytologies (HCP) is very challenging as a majority is diagnosed as indeterminate. Prior studies have reported various cytologic features to help distinguish non‐neoplastic (NN) from neoplastic and malignant lesions but had… read more here.
Keywords: risk; cell predominant; rthle cell; cytology ... See more keywords
Widespread Chromosomal Losses and Mitochondrial DNA Alterations as Genetic Drivers in Hürthle Cell Carcinoma.
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DOI: 10.1016/j.ccell.2018.06.013
Abstract: Hürthle cell carcinoma of the thyroid (HCC) is a form of thyroid cancer recalcitrant to radioiodine therapy that exhibits an accumulation of mitochondria. We performed whole-exome sequencing on a cohort of primary, recurrent, and metastatic… read more here.
Keywords: chromosomal losses; widespread chromosomal; cell carcinoma; cell ... See more keywords
Typical manifestations of Hürthle cell adenoma of the thyroid on contrast-enhanced CT
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DOI: 10.1097/md.0000000000015866
Abstract: Abstract Rationale: Hürthle cell adenoma (HCA) of the thyroid is a rare thyroid tumor, and there are limited studies on the contrast-enhanced computed tomography (CT). Patient concerns: We report the case of a 63-year-old woman… read more here.
Keywords: thyroid; cell adenoma; contrast enhanced; rthle cell ... See more keywords
Differential Expression of Glycolysis-Related Proteins in Follicular Neoplasms versus Hürthle Cell Neoplasms: A Retrospective Analysis
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DOI: 10.1155/2017/6230294
Abstract: Purpose Although currently classified as variants of follicular neoplasms (FNs), Hürthle cell neoplasms (HCNs) exhibit distinct biological characteristics. Hence, the metabolism of both neoplasms may also be different. The aims of this study were to… read more here.
Keywords: glycolysis related; expression; rthle cell;
Ultrasonographic characteristics of Hürthle cell neoplasms: prediction of malignancy
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DOI: 10.14366/usg.21264
Abstract: Purpose This study investigated the ultrasound (US) features of malignancy in patients with Hürthle cell neoplasms (HCNs) of the thyroid gland. Methods The present study included 139 HCNs that had undergone surgical excision at a… read more here.
Keywords: malignancy; tumor size; cell neoplasms; rthle cell ... See more keywords
Molecular profile of Hürthle cell carcinomas: recurrent mutations in the Wnt/β-catenin pathway.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of endocrinology"
DOI: 10.1530/eje-20-0597
Abstract: Objective Genomic alterations in Hürthle cell carcinomas (HCC) include chromosomal losses, mitochondrial DNA mutations, and changes in the expression profile of the PI3K-AKT-mTOR and Wnt/β-catenin pathways. This study aimed at characterizing the mutational profile of… read more here.
Keywords: wnt catenin; hcc; catenin pathway; profile ... See more keywords
Unique landscape of widespread chromosomal losses in Hürthle cell carcinoma.
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DOI: 10.1530/erc-18-0481
Abstract: In their back-to-back published articles "Integrated Genomic Analysis of Hürthle Cell Cancer Reveals Oncogenic Drivers, Recurrent Mitochondrial Mutations, and Unique Chromosomal Landscapes" and "Widespread Chromosomal Losses and Mitochondrial DNA Alterations as Genetic Drivers in Hürthle… read more here.
Keywords: chromosomal losses; widespread chromosomal; cell carcinoma; cell ... See more keywords
Targeted Treatment Options of Recurrent Radioactive Iodine Refractory Hürthle Cell Cancer
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DOI: 10.3390/cancers11081185
Abstract: Objective: To evaluate the efficacy and treatment rationale of Hürthle cell carcinoma (HCC) following a patient with progressive and metastatic HCC. HCC was recently shown to harbor a distinct genetic make-up and the mitogen-activated protein… read more here.
Keywords: hcc; treatment; treatment options; cancer ... See more keywords