Abstract 3413: RTK/SHP2 dependency and feedback adaptation to MEK inhibition defines sensitivity of RAS-mutant proteins to SHP2 inhibitor-based therapies
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DOI: 10.1158/1538-7445.am2023-3413
Abstract: Activating RAS mutations constitute the majority of recurrent mutations found in MAPK-driven human tumors. However, RAS mutants have long been considered undruggable, and therefore efforts have been predominantly focused on targeting downstream MAPK signaling. We… read more here.
Keywords: ras mutant; inhibition; rtk shp2; shp2i ... See more keywords