Comprehensive targeting of resistance to inhibition of RTK signaling pathways by using glucocorticoids.
Sign Up to like & getrecommendations! Published in 2021 at "Nature communications"
DOI: 10.1038/s41467-021-27276-7
Abstract: Inhibition of RTK pathways in cancer triggers an adaptive response that promotes therapeutic resistance. Because the adaptive response is multifaceted, the optimal approach to blunting it remains undetermined. TNF upregulation is a biologically significant response… read more here.
Keywords: inhibition; resistance; egfr inhibition; inhibition rtk ... See more keywords
Abstract 5046: Bisphenol AF promotes ER+ breast cancer through amphiregulin-mediated ER-RTK signaling crosstalk
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-5046
Abstract: Bisphenol AF (BPAF), a BPA analog, is widely used in the manufacturing of plastics, and has been detected in the environment and in human urine samples. Since BPAF may exhibit more potent endocrine-disrupting activities than… read more here.
Keywords: rtk signaling; breast cancer; crosstalk; cancer ... See more keywords
RAF1 deficiency causes a lethal syndrome that underscores RTK signaling during embryogenesis
Sign Up to like & getrecommendations! Published in 2023 at "EMBO Molecular Medicine"
DOI: 10.15252/emmm.202217078
Abstract: Somatic and germline gain‐of‐function point mutations in RAF, one of the first oncogenes to be discovered in humans, delineate a group of tumor‐prone syndromes known as the RASopathies. In this study, we document the first… read more here.
Keywords: lethal syndrome; causes lethal; rtk signaling; raf1 deficiency ... See more keywords