Recombinant Tissue Plasminogen Activator-conjugated Nanoparticles Effectively Targets Thrombolysis in a Rat Model of Middle Cerebral Artery Occlusion
Sign Up to like & getrecommendations! Published in 2018 at "Current Medical Science"
DOI: 10.1007/s11596-018-1896-z
Abstract: SummaryThe efficacy and safety of recombinant tissue plasminogen activator (rtPA) need to be improved due to its low bioavailability and requirement of large dose administration. The purpose of this study was to develop a fibrin-targeted… read more here.
Keywords: plasminogen activator; tissue plasminogen; recombinant tissue; rtpa ... See more keywords
Age-specific Cost Effectiveness of Using Intravenous Recombinant Tissue Plasminogen Activator for Treating Acute Ischemic Stroke
Sign Up to like & getrecommendations! Published in 2017 at "American journal of preventive medicine"
DOI: 10.1016/j.amepre.2017.06.004
Abstract: Introduction Studies have demonstrated that intravenous recombinant tissue plasminogen activator (IV rtPA) is a cost-effective treatment for acute ischemic stroke. Age-specific cost effectiveness has not been well examined. This study estimated age-specific incremental cost-effectiveness ratios… read more here.
Keywords: aged years; cost; rtpa; cost effectiveness ... See more keywords
Response to commentary on JTH‐2020–01486.R1 ‐ Quantification of microbubble‐induced sonothrombolysis in an ex‐vivo non‐human primate model
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Thrombosis and Haemostasis"
DOI: 10.1111/jth.15225
Abstract: The use of a low dose of rtPA by Hinds et al. (40% of the usual lytic dose, 0.15 mg/kg and after 0.3 mg/kg, 9–12 kg juvenile baboons) could be, in part, responsible for the… read more here.
Keywords: reduced dose; vivo; dose rtpa; rtpa ... See more keywords
Amino-Fucoidan as a Vector for rtPA-Induced Fibrinolysis in Experimental Thrombotic Events.
Sign Up to like & getrecommendations! Published in 2018 at "Thrombosis and haemostasis"
DOI: 10.1160/th17-02-0132
Abstract: Acute ischaemic stroke, myocardial infarction and pulmonary embolism are the main causes of mortality and morbidity worldwide. Thrombolysis by intravenous injection of recombinant tissue plasminogen activator (rtPA) remains the most common non-interventional treatment to recanalize… read more here.
Keywords: vector rtpa; fucoidan vector; induced fibrinolysis; rtpa ... See more keywords
Regional and national differences in stroke thrombolysis use and disparities in pricing, treatment availability, and coverage
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Stroke"
DOI: 10.1177/17474930221082446
Abstract: Background: Major disparities have been reported in recombinant tissue plasminogen activator (rtPA) availability among countries of different socioeconomic status. Aims: To characterize variability of rtPA price, its availability, and its association with and impact on… read more here.
Keywords: rtpa; country; availability; rtpa price ... See more keywords
Thrombolysis of a stroke patient with history of rtPA-associated angioedema.
Sign Up to like & getrecommendations! Published in 2017 at "Neurology: Clinical Practice"
DOI: 10.1212/cpj.0000000000000404
Abstract: Orolingual angioedema in acute ischemic stroke patients following IV recombinant tissue plasminogen activator (rtPA) treatment is a potentially life-threatening complication. It is estimated to occur in 1.7%–7.9% of all cases.1,2 This complication is considered to… read more here.
Keywords: rtpa related; history rtpa; orolingual angioedema; rtpa ... See more keywords
Plasminogen activator-coated nanobubbles targeting cell-bound β2-glycoprotein I as a novel thrombus-specific thrombolytic strategy.
Sign Up to like & getrecommendations! Published in 2022 at "Haematologica"
DOI: 10.3324/haematol.2022.281505
Abstract: Beta2-glycoprotein I (β2-GPI) is a serum protein widely recognized as the main target of antibodies present in patients with anti-phospholipid syndrome (APS). β2-GPI binds to activated endothelial cells, platelets and leukocytes, key players in thrombus… read more here.
Keywords: rtpa; plasminogen activator; cell bound; thrombus ... See more keywords
Seguridad y efectividad del rtPA en el ictus isquemico agudo en pacientes con cancer activo: estudio de casos y controles.
Sign Up to like & getrecommendations! Published in 2017 at "Revista De Neurologia"
DOI: 10.33588/rn.6501.2016510
Abstract: Introduccion. Los pacientes con cancer tiene un mayor riesgo de ictus debido a los efectos malignos directos e indirectos. La trombolisis intravenosa con activador tisular del plasminogeno recombinante (rtPA) constituye un tratamiento medico estandar para… read more here.
Keywords: ictus isquemico; pacientes con; con cancer; rtpa ... See more keywords
The Quinazoline Otaplimastat (SP-8203) Reduces the Hemorrhagic Transformation and Mortality Aggravated after Delayed rtPA-Induced Thrombolysis in Cerebral Ischemia
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23031403
Abstract: Acute ischemic stroke is the leading cause of morbidity and mortality worldwide. Recombinant tissue plasminogen activator (rtPA) is the only agent clinically approved by FDA for patients with acute ischemic stroke. However, delayed treatment of… read more here.
Keywords: delayed rtpa; ischemia; rtpa; hemorrhagic transformation ... See more keywords