Could the RTS,S/AS01 meningitis safety signal really be a protective effect of rabies vaccine?
Sign Up to like & getrecommendations! Published in 2017 at "Vaccine"
DOI: 10.1016/j.vaccine.2016.12.067
Abstract: The RTS,S/AS01 malaria vaccine has been associated with meningitis and cerebral malaria safety signals. Key characteristics of the meningitis signal include presence, in the 5-17month but not the 6-12week age group, of delayed and variable… read more here.
Keywords: rts as01; protective effect; safety; effect ... See more keywords
Immunogenicity and safety of the RTS,S/AS01 malaria vaccine co-administered with measles, rubella and yellow fever vaccines in Ghanaian children: A phase IIIb, multi-center, non-inferiority, randomized, open, controlled trial.
Sign Up to like & getrecommendations! Published in 2020 at "Vaccine"
DOI: 10.1016/j.vaccine.2020.03.014
Abstract: BACKGROUND To optimize vaccine implementation visits for young children, it could be efficient to administer the first RTS,S/AS01 malaria vaccine dose during the Expanded Programme on Immunization (EPI) visit at 6 months of age together with… read more here.
Keywords: months age; safety; non inferiority; rts as01 ... See more keywords
RTS,S/AS01 malaria vaccine mismatch observed among Plasmodium falciparum isolates from southern and central Africa and globally
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-24585-8
Abstract: The RTS,S/AS01 malaria vaccine encompasses the central repeats and C-terminal of Plasmodium falciparum circumsporozoite protein (PfCSP). Although no Phase II clinical trial studies observed evidence of strain-specific immunity, recent studies show a decrease in vaccine… read more here.
Keywords: diversity; rts as01; plasmodium falciparum; malaria vaccine ... See more keywords
Mapping functional humoral correlates of protection against malaria challenge following RTS,S/AS01 vaccination
Sign Up to like & getrecommendations! Published in 2020 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.abb4757
Abstract: A combination of two Fc antibody features that leverage innate immune function predicts protection from malaria challenge after RTS,S/AS01 vaccination. Above and beyond antibody abundance Vaccine development can be hampered by a lack of clear… read more here.
Keywords: protection; correlates protection; rts as01; serology ... See more keywords
The thermostability of the RTS,S/AS01 malaria vaccine can be increased by co-lyophilizing RTS,S and AS01
Sign Up to like & getrecommendations! Published in 2020 at "Malaria Journal"
DOI: 10.1186/s12936-020-03253-1
Abstract: Background Developing thermostable vaccines is a challenge for pharmaceutical companies due to the inherent instability of biological molecules in aqueous solution. The problem is even more stringent in regions subjected to high temperatures in which… read more here.
Keywords: lyophilizing rts; rts as01; thermostability rts; vaccine ... See more keywords
“I would have to sell things in order to get the money”: A qualitative exploration of willingness to pay for the RTS,S/AS01 malaria vaccine in the Volta region, Ghana
Sign Up to like & getrecommendations! Published in 2022 at "PLoS ONE"
DOI: 10.1371/journal.pone.0268009
Abstract: Background Malaria morbidity and mortality remain a challenge in Ghana. A promising childhood vaccine is being piloted in Ghana, however with the loss of its low-income status, Ghana is losing associated donor co-funding. User fees… read more here.
Keywords: ghana; rts as01; malaria vaccine; willingness pay ... See more keywords
Correlations between three ELISA protocols measurements of RTS,S/AS01-induced anti-CSP IgG antibodies
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DOI: 10.1371/journal.pone.0286117
Abstract: Background RTS,S/AS01 induced anti-circumsporozoite protein (CSP) IgG antibodies are associated with the vaccine efficacy. There is currently no international standardisation of the assays used in the measurement of anti-CSP IgG antibody concentrations for use in… read more here.
Keywords: csp; igg antibodies; rts as01; anti csp ... See more keywords
Mosquirix™ RTS, S/AS01 Vaccine Development, Immunogenicity, and Efficacy
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DOI: 10.3390/vaccines10050713
Abstract: Malaria is a parasitic infection caused by bites from Plasmodium falciparum (P. falciparum)-infected mosquitoes with a present scale of symptoms ranging from moderate fever to neurological disorders. P. falciparum is the most lethal of the… read more here.
Keywords: immunization; rts as01; development; vaccine development ... See more keywords
A delayed fractionated dose RTS,S AS01 vaccine regimen mediates protection via improved T follicular helper and B cell responses
Sign Up to like & getrecommendations! Published in 2020 at "eLife"
DOI: 10.7554/elife.51889
Abstract: Malaria-071, a controlled human malaria infection trial, demonstrated that administration of three doses of RTS,S/AS01 malaria vaccine given at one-month intervals was inferior to a delayed fractional dose (DFD) schedule (62.5% vs 86.7% protection, respectively).… read more here.
Keywords: protection; follicular helper; helper cell; cell ... See more keywords
Transcriptional correlates of malaria in RTS,S/AS01-vaccinated African children: a matched case–control study
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.7554/elife.70393
Abstract: Background: In a phase 3 trial in African infants and children, the RTS,S/AS01 vaccine (GSK) showed moderate efficacy against clinical malaria. We sought to further understand RTS,S/AS01-induced immune responses associated with vaccine protection. Methods: Applying… read more here.
Keywords: matched case; control; case control; cell ... See more keywords