Antibody responses to the RTS,S/AS01E vaccine and Plasmodium falciparum antigens after a booster dose within the phase 3 trial in Mozambique.
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DOI: 10.1038/s41541-020-0192-7
Abstract: The RTS,S/AS01E vaccine has shown consistent but partial vaccine efficacy in a pediatric phase 3 clinical trial using a 3-dose immunization schedule. A fourth-dose 18 months after the primary vaccination was shown to restore the… read more here.
Keywords: trial; booster; rts as01e; booster dose ... See more keywords
Antigen-stimulated PBMC transcriptional protective signatures for malaria immunization
Sign Up to like & getrecommendations! Published in 2020 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.aay8924
Abstract: Transcriptomic signatures before and after immunization predict protection against malaria induced by sporozoite and RTS,S/AS01E immunization. Predicting protection A highly effective malaria vaccine would save many lives but correlates of protection remain ill-defined. Moncunill et… read more here.
Keywords: protection; immunization; trial; preimmunization ... See more keywords
Strong off-target antibody reactivity to malarial antigens induced by RTS,S/AS01E vaccination is associated with protection.
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DOI: 10.1172/jci.insight.158030
Abstract: The RTS,S/AS01E vaccine targets the circumsporozoite protein (CSP) of the Plasmodium falciparum parasite. Using protein microarrays, levels of IgG to 1,000 P. falciparum antigens were measured in 2,138 infants (age 6-12 weeks) and children (age… read more here.
Keywords: vaccination; igg; rts as01e; anti csp ... See more keywords