Hot Melted Amorphous Solid Dispersion of Ritonavir With PVPVA and Span 60: Physicochemical Characterization and In Vitro Assessment
Sign Up to like & getrecommendations! Published in 2025 at "Polymers for Advanced Technologies"
DOI: 10.1002/pat.70301
Abstract: The therapeutic activity of ritonavir (RTV), an antiretroviral drug, is limited due to its poor aqueous solubility and permeability. Amorphous solid dispersion (ASD) by the hot melt technique emerges as an outstanding approach for the… read more here.
Keywords: amorphous solid; solid dispersion; ritonavir; drug ... See more keywords
Safety and immunogenicity of an HIV vaccine trial with DNA prime and replicating vaccinia boost
Sign Up to like & getrecommendations! Published in 2025 at "Signal Transduction and Targeted Therapy"
DOI: 10.1038/s41392-025-02259-y
Abstract: Developing a safe and effective vaccine remains a global priority for ending the human immunodeficiency virus (HIV) pandemic. All HIV vaccine trials with protein, DNA, non-replication vector or their combinations failed in the past. We… read more here.
Keywords: hiv vaccine; replicating vaccinia; boost; vaccine ... See more keywords
Investigation of binding characteristics of ritonavir with calf thymus DNA with the help of spectroscopic techniques and molecular simulation
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2020.1844057
Abstract: Abstract The binding behavior of ritonavir (RTV), a HIV/AIDS protease inhibitor, with ct-DNA was characterized through multiple testing technologies and theoretical calculation. The findings revealed that the RTV–DNA complex was formed through the noncovalent interaction… read more here.
Keywords: dna; rtv; investigation binding; binding characteristics ... See more keywords
Enhancement of the aqueous solubility and permeability of a poorly water soluble drug ritonavir via lyophilized milk-based solid dispersions
Sign Up to like & getrecommendations! Published in 2017 at "Pharmaceutical Development and Technology"
DOI: 10.1080/10837450.2016.1193193
Abstract: Abstract In the present study, a lyophilized milk-based solid dispersion (SD) of ritonavir (RTV) was developed with the goal of improving its aqueous solubility. The SD was prepared by lyophilization, and characterized for its physicochemical… read more here.
Keywords: rtv; aqueous solubility; formulation; lyophilized milk ... See more keywords
Priming “American carnage:” reality television and Donald J. Trump
Sign Up to like & getrecommendations! Published in 2024 at "Critical Studies in Media Communication"
DOI: 10.1080/15295036.2024.2392806
Abstract: ABSTRACT This essay uncovers how and why so many U.S. Americans so easily and so gleefully accepted the tenets of Donald J. Trump’s Make America Great Again (MAGA) platform by arguing that U.S. American culture… read more here.
Keywords: reality; donald trump; culture; rtv ... See more keywords
Health Monitoring of RTV Silicone Rubber Coating on Insulators Based on Multimode Features of Active Infrared Thermography
Sign Up to like & getrecommendations! Published in 2022 at "IEEE Transactions on Instrumentation and Measurement"
DOI: 10.1109/tim.2022.3164159
Abstract: Poor quality of room-temperature vulcanized silicone rubber (RTV-SIR) coating on insulators, such as damages, inclusions, debonding, uneven or substandard thickness, and so on, seriously deteriorates the external insulation performance and brings potential threats to the… read more here.
Keywords: coating insulators; frequency; silicone rubber; rtv ... See more keywords
Improvement in Bioavailability and Pharmacokinetic Characteristics of Efavirenz with Booster Dose of Ritonavir in PEGylated PAMAM G4 Dendrimers
Sign Up to like & getrecommendations! Published in 2022 at "AAPS PharmSciTech"
DOI: 10.1208/s12249-022-02315-8
Abstract: Efavirenz (EFV) with a booster dose of ritonavir (RTV) (EFV-RTV) inhibits the metabolism of EFV and improves its bioavailability. However, inadequate organ perfusion with surface permeability glycoprotein (P-gp) efflux sustains the viable HIV. Hence, the… read more here.
Keywords: ppg4er; booster dose; efv; bioavailability ... See more keywords
UiO-67 Metal–Organic Framework as Advanced Adsorbent for Antiviral Drugs from Water Environment
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DOI: 10.3390/catal14090573
Abstract: Metal–organic frameworks (MOFs) have attained significant usage as adsorbents for antiviral medicines in contemporary times. This study focused on synthesizing a UiO-67 metal–organic framework using the hydrothermal method. The synthesized framework was then characterized using… read more here.
Keywords: framework; adsorption; lpv; rtv ... See more keywords
The Development of an Oral Solution Containing Nirmatrelvir and Ritonavir and Assessment of Its Pharmacokinetics and Stability
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DOI: 10.3390/pharmaceutics16010109
Abstract: Paxlovid®, a co-packaged medication comprised of separate tablets containing two active ingredients, nirmatrelvir (NRV) and ritonavir (RTV), exhibits good effectiveness against coronavirus disease 2019 (COVID-19). However, the size of the NRV/RTV tablets makes them difficult… read more here.
Keywords: oral liquid; stability; solution; rtv ... See more keywords
Study on the Influence of Accelerated Aging on the Properties of an RTV Anti-Pollution Flashover Coating
Sign Up to like & getrecommendations! Published in 2023 at "Polymers"
DOI: 10.3390/polym15030751
Abstract: The purpose of this work is to study the accelerated aging behavior of a room-temperature vulcanized (RTV) silicone rubber anti-pollution flashover coating. Red, blue and gray RTV rubber samples were selected to prepare coatings on… read more here.
Keywords: pollution flashover; flashover coating; anti pollution; rtv ... See more keywords
Three-Dimensionally Printed Expandable Structural Electronics Via Multi-Material Printing Room-Temperature-Vulcanizing (RTV) Silicone/Silver Flake Composite and RTV
Sign Up to like & getrecommendations! Published in 2023 at "Polymers"
DOI: 10.3390/polym15092003
Abstract: Three-dimensional (3D) printing has various applications in many fields, such as soft electronics, robotic systems, biomedical implants, and the recycling of thermoplastic composite materials. Three-dimensional printing, which was only previously available for prototyping, is currently… read more here.
Keywords: structural electronics; printing; multi material; expandable structural ... See more keywords