Anticancer activity of ruthenium(II) plumbagin complexes with polypyridyl as ancillary ligands via inhibiting energy metabolism and GADD45A-mediated cell cycle arrest.
Sign Up to like & getrecommendations! Published in 2022 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2022.114312
Abstract: To study the antitumor activity and action mechanism of Ru(II) polypyridyl plumbagin (PLN) complexes, four complexes [Ru(PLN)(DMSO)2]Cl (Ru1), [Ru(bpy)2(PLN)](PF6) (bpy is bipyridine) (Ru2), [Ru(phen)2(PLN)](PF6) (phen is 1,10-phenanthroline) (Ru3), and [Ru(DIP)2(PLN)](PF6) (DIP is 4,7-diphenyl-1,10-phenanthroline) (Ru4) were… read more here.
Keywords: gadd45a; ru4; ru3 ru4; cell cycle ... See more keywords
Development of Ion-Conductive and Vapoluminescent Porous Coordination Polymers Composed of Ruthenium(II) Metalloligand.
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DOI: 10.1021/acs.inorgchem.6b03123
Abstract: We synthesized two new porous coordination polymers (PCPs) {Ln7(OH)5[Ru(dcbpy)3]4ยท4nH2O} (Ln7-Ru4; Ln = Ce, Nd) composed of the luminescent ruthenium(II) metalloligand [Ru(4,4'-dcbpy)3]4- ([4Ru]; 4,4'-dcbpy = 4,4'-dicarboxy-2,2'-bipyridine) and lanthanide ions Ln3+ (Ln = Ce, Nd). These two… read more here.
Keywords: ln7 ru4; porous coordination; ru4; ion ... See more keywords
Cyclometalated Ru(II)-NHC complexes with phenanthroline ligands induce apoptosis mediated by mitochondria and endoplasmic reticulum stress in cancer cells.
Sign Up to like & getrecommendations! Published in 2023 at "Dalton transactions"
DOI: 10.1039/d2dt03405k
Abstract: The exploration of ruthenium complexes as anticancer drugs has been the focus of intense investigation. In this study, we synthesized and characterized four C,N-cyclometalated ruthenium(II) complexes (Ru1-Ru4) coordinated with pyridine-functionalized N-heterocyclic carbene (NHC) and auxiliary… read more here.
Keywords: endoplasmic reticulum; ru3 ru4; reticulum stress; cyclometalated nhc ... See more keywords