Discovery of rubiarbonone C as a selective inhibitor of cytochrome P450 4F enzymes
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DOI: 10.1007/s00204-018-2315-8
Abstract: Cytochrome P450 (CYP) enzymes, particularly CYP4A/4F, are the major ω-hydroxylases of arachidonic acid (AA) that can produce 20-hydroxyeicosatetraenoic acid (20-HETE). Although there are dissimilarities in substrate specificity, tissue distribution, and gene regulation between CYP4A and… read more here.
Keywords: cytochrome p450; selective inhibitor; inhibitor; rubiarbonone selective ... See more keywords