On identifying low energy conformational excited states with differential ruggedness in human γS-crystallin promoting severe infantile cataracts.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.05.071
Abstract: Transient excited states in proteins can be accurately probed from temperature dependence of amide proton (1HN) chemical shifts displaying significant curvatures. Characterizing these near-native alternative states is of high therapeutic relevance in conformational diseases wherein… read more here.
Keywords: ruggedness human; energy; infantile cataracts; excited states ... See more keywords