N‐end rule pathway inhibitor sensitizes cancer cells to antineoplastic agents by regulating XIAP and RAD21 protein expression
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.29326
Abstract: Anticancer drugs exert their effects on cancer cells by deregulating many pathways linked to cell cycle, apoptosis, etc. but cancer cells gradually become resistive against anticancer drugs, thereby necessitating the development of newer generation anticancer… read more here.
Keywords: rule pathway; cancer cells; cancer; anticancer ... See more keywords
Pro(moting) the Turnover of Gluconeogenic Enzymes by a New Branch of the N-end Rule Pathway.
Sign Up to like & getrecommendations! Published in 2017 at "Trends in biochemical sciences"
DOI: 10.1016/j.tibs.2017.03.006
Abstract: The N-end rule pathway is a set of protein degradation systems that link the in vivo stability of a protein to its N-terminal residue. A recent paper from Alexander Varshavsky's laboratory [1] identifies a new… read more here.
Keywords: rule pathway; branch end; end rule; new branch ... See more keywords
Understanding the Pro/N-end rule pathway
Sign Up to like & getrecommendations! Published in 2018 at "Nature Chemical Biology"
DOI: 10.1038/s41589-018-0045-0
Abstract: Regulated destruction of proteins underlies just about everything a cell does. A structural study of human Gid4, the N-recognin of the Pro/N-end rule pathway that targets proteins through their N-terminal proline, illuminates the recognition of… read more here.
Keywords: understanding pro; rule pathway; end rule; pro end ... See more keywords
Regulation of autophagic proteolysis by the N-recognin SQSTM1/p62 of the N-end rule pathway
Sign Up to like & getrecommendations! Published in 2018 at "Autophagy"
DOI: 10.1080/15548627.2017.1415190
Abstract: ABSTRACT In macroautophagy/autophagy, cargoes are collected by specific receptors, such as SQSTM1/p62 (sequestosome 1), and delivered to phagophores for lysosomal degradation. To date, little is known about how cells modulate SQSTM1 activity and autophagosome biogenesis… read more here.
Keywords: sqstm1; rule pathway; end rule; sqstm1 p62 ... See more keywords
The N-recognin UBR4 of the N-end rule pathway is targeted to and required for the biogenesis of the early endosome
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cell Science"
DOI: 10.1242/jcs.217646
Abstract: ABSTRACT The N-end rule pathway is a proteolytic system in which single N-terminal residues of proteins act as N-degrons. These degrons are recognized by N-recognins, facilitating substrate degradation via the ubiquitin (Ub) proteasome system (UPS)… read more here.
Keywords: recognin ubr4; rule pathway; biogenesis early; end rule ... See more keywords
The N-end rule pathway and Ubr1 enforce protein compartmentalization via P2-encoded cellular location signals
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cell Science"
DOI: 10.1242/jcs.231662
Abstract: ABSTRACT The Arg/N-end rule pathway and Ubr1, a ubiquitin E3 ligase conserved from yeast to humans, is involved in the degradation of misfolded proteins in the cytosol. However, the root physiological purpose of this activity… read more here.
Keywords: rule pathway; end rule; cellular location; pathway ubr1 ... See more keywords