Novel ETV6-RUNX1 Mouse Model to Study the Role of ELF-MF in Childhood B-Acute Lymphoblastic Leukemia: a Pilot Study.
Sign Up to like & getrecommendations! Published in 2019 at "Bioelectromagnetics"
DOI: 10.1002/bem.22193
Abstract: Exposure to extremely low-frequency magnetic fields (ELF-MFs) has been classified by the International Agency for Research on Cancer (IARC) as "possibly carcinogenic to humans," based on limited scientific evidence concerning childhood leukemia. This assessment emphasized… read more here.
Keywords: etv6 runx1; runx1; study; leukemia ... See more keywords
MiR-199a-3p Restrains Foaming and Inflammation by Regulating RUNX1 in Macrophages
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Biotechnology"
DOI: 10.1007/s12033-022-00484-2
Abstract: MiR-199a-3p was reported decreased in serum of coronary heart disease patients and human atherosclerotic plaques. This study aims to investigate the roles of miR-199a-3p in atherosclerosis (AS). AS was induced in ApoE−/− mice via high… read more here.
Keywords: mir 199a; raw264 cells; ldl induced; runx1 ... See more keywords
Acute myeloid leukemia with t(14;21) involving RUNX1 and SYNE2: A novel favorable-risk translocation?
Sign Up to like & getrecommendations! Published in 2017 at "Cancer genetics"
DOI: 10.1016/j.cancergen.2017.07.002
Abstract: In acute myeloid leukemia (AML), a translocation between chromosomes 8q22 and 21q22 leads to the RUNX1-RUNXT1 fusion gene which, in the absence of a concomitant KIT mutation, generally portends a more favorable prognosis. Translocations at… read more here.
Keywords: risk; myeloid leukemia; runx1; translocation ... See more keywords
2010 - IDENTIFYING NECESSARY CHROMATIN STATES AND TARGETS FOR HEMOGENIC SPECIFICATION AND REPROGRAMMING
Sign Up to like & getrecommendations! Published in 2019 at "Experimental Hematology"
DOI: 10.1016/j.exphem.2019.06.284
Abstract: Hematopoietic stem cells (HSCs) originate from a subset of endothelium in the embryo known as hemogenic endothelium. Hemogenic endothelium must undergo an endothelial to hematopoietic transition (EHT) to form HSCs. EHT requires the activity of… read more here.
Keywords: chromatin; fetal endothelium; endothelium; specification ... See more keywords
RUNX1 EXPRESSION IN NG2+ PERIVASCULAR CELLS IS REQUIRED FOR PROPER AORTIC EMBRYONIC HAEMATOPOIETIC ACTIVITY IN VIVO
Sign Up to like & getrecommendations! Published in 2019 at "Experimental Hematology"
DOI: 10.1016/j.exphem.2019.06.312
Abstract: Insight into the role of the niche in which the first haematopoietic stem cells (HSCs) emerge in vivo is still lacking. Cells expressing NG2, a cell surface proteoglycan found in both vasculogenic and angiogenic vasculature,… read more here.
Keywords: expression; ng2 cells; haematopoietic activity; vivo ... See more keywords
3095 – PATHOGENIC RUNX1 MUTATIONS CAUSE DIFFERENT MALIGNANCIES BY UNIQUELY DISRUPTING GENE REGULATION HUBS
Sign Up to like & getrecommendations! Published in 2020 at "Experimental Hematology"
DOI: 10.1016/j.exphem.2020.09.108
Abstract: RUNX1 is a master haematopoietic transcription factor with cell-type dependent functions and thus RUNX1 mutations are seen in a range of haematological disorders. To understand the molecular basis of how different types of RUNX1 mutations… read more here.
Keywords: runx1 mutations; gene; runx1 binding; runx1 evi1 ... See more keywords
Brown adipose tissue transplantation ameliorates diabetic nephropathy through the miR-30b pathway by targeting Runx1.
Sign Up to like & getrecommendations! Published in 2021 at "Metabolism: clinical and experimental"
DOI: 10.1016/j.metabol.2021.154916
Abstract: OBJECTIVE Adipose tissue is a major source of circulating microRNAs (miRNAs) that can regulate target genes in distant organs. However, the role of brown adipose tissue (BAT) in diabetic kidney disease (DKD) is still unknown.… read more here.
Keywords: adipose tissue; runx1; bat; mir 30b ... See more keywords
Recurrent somatic JAK-STAT pathway variants within a RUNX1-mutated pedigree
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Human Genetics"
DOI: 10.1038/ejhg.2017.80
Abstract: Germline variants within the transcription factor RUNX1 are associated with familial platelet disorder and acute leukemia in over 40% of carriers. At present, the somatic events triggering leukemic transformation appear heterogeneous and profiles of leukemia… read more here.
Keywords: stat pathway; runx1; jak stat; variants within ... See more keywords
Spectrum of abnormalities and clonal transformation in germline RUNX1 familial platelet disorder and a genomic comparative analysis with somatic RUNX1 mutations in MDS/MPN overlap neoplasms
Sign Up to like & getrecommendations! Published in 2020 at "Leukemia"
DOI: 10.1038/s41375-020-0752-x
Abstract: The Runt-related transcription factor 1 (RUNX1) gene encodes a transcription factor that plays a crucial role in embryogenesis and definitive hematopoiesis [1]. Germline RUNX1 mutations (RUNX1) result in a familial platelet disorder with propensity to… read more here.
Keywords: germline runx1; somatic runx1; runx1; mpn overlap ... See more keywords
Runx1-Stat3-Tgfb3 signaling network regulating the anterior palatal development
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-29681-3
Abstract: Runx1 deficiency results in an anteriorly specific cleft palate at the boundary between the primary and secondary palates and in the first rugae area of the secondary palate in mice. However, the cellular and molecular… read more here.
Keywords: tgfb3; stat3 tgfb3; runx1; tgfb3 signaling ... See more keywords
Gene of the issue: RUNX1 mutations and inherited bleeding
Sign Up to like & getrecommendations! Published in 2017 at "Platelets"
DOI: 10.1080/09537104.2017.1280151
Abstract: Familial platelet disorder with predisposition to acute myelogenous leukemia (FPD/AML) (OMIM #601399) is an autosomal dominant disorder characterized by quantitative and qualitative platelet defects and an increased risk of AML. FPD/AML shares phenotypic similarities with… read more here.
Keywords: runx1; fpd aml; runx1 defects; gene ... See more keywords