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   Articles with "runx1" as a keyword



Novel ETV6-RUNX1 Mouse Model to Study the Role of ELF-MF in Childhood B-Acute Lymphoblastic Leukemia: a Pilot Study.

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recommendations! Published in 2019 at "Bioelectromagnetics"

DOI: 10.1002/bem.22193

Abstract: Exposure to extremely low-frequency magnetic fields (ELF-MFs) has been classified by the International Agency for Research on Cancer (IARC) as "possibly carcinogenic to humans," based on limited scientific evidence concerning childhood leukemia. This assessment emphasized… read more here.

Keywords: etv6 runx1; runx1; study; leukemia ... See more keywords

A novel t(X;21)(p11.4;q22.12) translocation adds to the role of BCOR and RUNX1 in myelodysplastic syndromes and acute myeloid leukemias

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recommendations! Published in 2024 at "Genes"

DOI: 10.1002/gcc.23235

Abstract: In myeloid neoplasms, both fusion genes and gene mutations are well‐established events identifying clinicopathological entities. In this study, we present a thus far undescribed t(X;21)(p11.4;q22.12) in five cases with myelodysplastic syndrome (MDS) or acute myeloid… read more here.

Keywords: runx1; acute myeloid; bcor; p11 q22 ... See more keywords

RUNX1::MIR99AHG Chimera in Acute Myeloid Leukemia

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recommendations! Published in 2024 at "Genes"

DOI: 10.1002/gcc.23272

Abstract: RUNX1 fuses with over 70 different partner genes in hematological neoplasms. While common RUNX1 chimeras have been extensively studied and their prognosis is well established, our current understanding of less common RUNX1 chimeras is limited.… read more here.

Keywords: runx1; runx1 mir99ahg; acute myeloid; mir99ahg chimera ... See more keywords
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RUNX1 Induces Central Neuropathic Pain by Activating Microglia and Triggering the Inflammatory Response in Spinal Cord Injury.

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recommendations! Published in 2025 at "Inflammation"

DOI: 10.1007/s10753-025-02336-y

Abstract: Runt-related transcription factor 1 (RUNX1) is a highly conserved transcription factor involved in immune regulation, inflammation, and nociceptive neuron differentiation. However, its role in central neuropathic pain (CNP) induced by SCI remains unclear. Here, we… read more here.

Keywords: central neuropathic; runx1; runx1 knockdown; injury ... See more keywords

MiR-199a-3p Restrains Foaming and Inflammation by Regulating RUNX1 in Macrophages

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recommendations! Published in 2022 at "Molecular Biotechnology"

DOI: 10.1007/s12033-022-00484-2

Abstract: MiR-199a-3p was reported decreased in serum of coronary heart disease patients and human atherosclerotic plaques. This study aims to investigate the roles of miR-199a-3p in atherosclerosis (AS). AS was induced in ApoE−/− mice via high… read more here.

Keywords: mir 199a; raw264 cells; ldl induced; runx1 ... See more keywords

Acute myeloid leukemia with t(14;21) involving RUNX1 and SYNE2: A novel favorable-risk translocation?

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recommendations! Published in 2017 at "Cancer genetics"

DOI: 10.1016/j.cancergen.2017.07.002

Abstract: In acute myeloid leukemia (AML), a translocation between chromosomes 8q22 and 21q22 leads to the RUNX1-RUNXT1 fusion gene which, in the absence of a concomitant KIT mutation, generally portends a more favorable prognosis. Translocations at… read more here.

Keywords: risk; myeloid leukemia; runx1; translocation ... See more keywords

2010 - IDENTIFYING NECESSARY CHROMATIN STATES AND TARGETS FOR HEMOGENIC SPECIFICATION AND REPROGRAMMING

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recommendations! Published in 2019 at "Experimental Hematology"

DOI: 10.1016/j.exphem.2019.06.284

Abstract: Hematopoietic stem cells (HSCs) originate from a subset of endothelium in the embryo known as hemogenic endothelium. Hemogenic endothelium must undergo an endothelial to hematopoietic transition (EHT) to form HSCs. EHT requires the activity of… read more here.

Keywords: chromatin; fetal endothelium; endothelium; specification ... See more keywords

RUNX1 EXPRESSION IN NG2+ PERIVASCULAR CELLS IS REQUIRED FOR PROPER AORTIC EMBRYONIC HAEMATOPOIETIC ACTIVITY IN VIVO

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recommendations! Published in 2019 at "Experimental Hematology"

DOI: 10.1016/j.exphem.2019.06.312

Abstract: Insight into the role of the niche in which the first haematopoietic stem cells (HSCs) emerge in vivo is still lacking. Cells expressing NG2, a cell surface proteoglycan found in both vasculogenic and angiogenic vasculature,… read more here.

Keywords: expression; ng2 cells; haematopoietic activity; vivo ... See more keywords

3095 – PATHOGENIC RUNX1 MUTATIONS CAUSE DIFFERENT MALIGNANCIES BY UNIQUELY DISRUPTING GENE REGULATION HUBS

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recommendations! Published in 2020 at "Experimental Hematology"

DOI: 10.1016/j.exphem.2020.09.108

Abstract: RUNX1 is a master haematopoietic transcription factor with cell-type dependent functions and thus RUNX1 mutations are seen in a range of haematological disorders. To understand the molecular basis of how different types of RUNX1 mutations… read more here.

Keywords: runx1 mutations; gene; runx1 binding; runx1 evi1 ... See more keywords
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Brown adipose tissue transplantation ameliorates diabetic nephropathy through the miR-30b pathway by targeting Runx1.

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recommendations! Published in 2021 at "Metabolism: clinical and experimental"

DOI: 10.1016/j.metabol.2021.154916

Abstract: OBJECTIVE Adipose tissue is a major source of circulating microRNAs (miRNAs) that can regulate target genes in distant organs. However, the role of brown adipose tissue (BAT) in diabetic kidney disease (DKD) is still unknown.… read more here.

Keywords: adipose tissue; runx1; bat; mir 30b ... See more keywords

Recurrent somatic JAK-STAT pathway variants within a RUNX1-mutated pedigree

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recommendations! Published in 2017 at "European Journal of Human Genetics"

DOI: 10.1038/ejhg.2017.80

Abstract: Germline variants within the transcription factor RUNX1 are associated with familial platelet disorder and acute leukemia in over 40% of carriers. At present, the somatic events triggering leukemic transformation appear heterogeneous and profiles of leukemia… read more here.

Keywords: stat pathway; runx1; jak stat; variants within ... See more keywords