3095 – PATHOGENIC RUNX1 MUTATIONS CAUSE DIFFERENT MALIGNANCIES BY UNIQUELY DISRUPTING GENE REGULATION HUBS
Sign Up to like & getrecommendations! Published in 2020 at "Experimental Hematology"
DOI: 10.1016/j.exphem.2020.09.108
Abstract: RUNX1 is a master haematopoietic transcription factor with cell-type dependent functions and thus RUNX1 mutations are seen in a range of haematological disorders. To understand the molecular basis of how different types of RUNX1 mutations… read more here.
Keywords: runx1 mutations; gene; runx1 binding; runx1 evi1 ... See more keywords
RUNX1-EVI1 induces dysplastic hematopoiesis and acute leukemia of the megakaryocytic lineage in mice.
Sign Up to like & getrecommendations! Published in 2018 at "Leukemia research"
DOI: 10.1016/j.leukres.2018.09.015
Abstract: The RUNX1-EVI1 gene generated by the t(3;21) translocation encodes a chimeric transcription factor and is a causative gene in the development of de novo acute megakaryoblastic leukemia and leukemic transformation of hematopoietic stem cell tumors.… read more here.
Keywords: hematopoiesis; leukemia; runx1 evi1; mice ... See more keywords