The RUNX1/RUNX1T1 network: translating insights into therapeutic options
Sign Up to like & getrecommendations! Published in 2020 at "Experimental Hematology"
DOI: 10.1016/j.exphem.2020.11.005
Abstract: Highlights • A RUNX1/RUNX1T1-associated gene expression network drives acute myeloid leukemia.• RUNX1/RUNX1T1 dysregulates gene expression at multiple levels.• Interrogation of the RUNX1/RUNX1T1 network by RNA interference or CRISPR screens identifies novel therapeutic targets.• RUNX1/RUNX1T1 drives… read more here.
Keywords: network translating; runx1 runx1t1; runx1t1 network; translating insights ... See more keywords
Single base substitution and insertion/deletion mutational signatures in adult core binding factor acute myeloid leukemia
Sign Up to like & getrecommendations! Published in 2022 at "Leukemia"
DOI: 10.1038/s41375-022-01552-x
Abstract: TO THE EDITOR Single base substitutions (SBSs) and insertions/deletions (indels; IDs) arise through several mechanisms such as errors during DNA replication/repair and exposures to mutagens, with the different mutational processes occasionally generating specific mutational signatures.… read more here.
Keywords: cancer; runx1 runx1t1; aml; mutational signatures ... See more keywords
Salmon‐coloured granules in residual acute myeloid leukaemia with t(8;21)(q22;q22.1); RUNX1‐RUNX1T1
Sign Up to like & getrecommendations! Published in 2021 at "British Journal of Haematology"
DOI: 10.1111/bjh.17307
Abstract: A 27-year-old female with a history of acute myeloid leukaemia (AML) with t(8;21)(q22;q22.1); RUNX1-RUNX1T1, in remission, presented for routine bone marrow (BM) followup. Her full blood count was normal. The BM aspirate film, however, showed… read more here.
Keywords: runx1 runx1t1; salmon coloured; coloured granules; q22 ... See more keywords
Immunohistochemical Staining to Identify Concomitant Systemic Mastocytosis in Acute Myeloid Leukemia with RUNX1::RUNX1T1
Sign Up to like & getrecommendations! Published in 2022 at "Annals of Laboratory Medicine"
DOI: 10.3343/alm.2022.42.6.678
Abstract: Systemic mastocytosis with associated hematological neoplasm (SM-AHN) poses diagnostic challenges because of the coexistence of atypical mast cell proliferation and hematological neoplasms. We assessed the presence of SM-AHN in patients with acute myeloid leukemia (AML)… read more here.
Keywords: runx1 runx1t1; runx1; myeloid leukemia; systemic mastocytosis ... See more keywords
Preemptive Immunotherapy for Minimal Residual Disease in Patients With t(8;21) Acute Myeloid Leukemia After Allogeneic Hematopoietic Stem Cell Transplantation
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2021.773394
Abstract: In patients with t(8;21) acute myeloid leukemia (AML), recurrent minimal residual disease (MRD) measured by RUNX1-RUNX1T1 transcript levels can predict relapse after allogeneic hematopoietic stem cell transplantation (allo-HSCT). This study aimed to compare the efficacy… read more here.
Keywords: runx1 runx1t1; level; ifn therapy;
Prognostic Impacts of D816V KIT Mutation and Peri-Transplant RUNX1–RUNX1T1 MRD Monitoring on Acute Myeloid Leukemia with RUNX1–RUNX1T1
Sign Up to like & getrecommendations! Published in 2021 at "Cancers"
DOI: 10.3390/cancers13020336
Abstract: Simple Summary Acute myeloid leukemia (AML) with RUNX1-RUNX1T1 is a heterogeneous disease entailing different prognoses. Patients with high-risk features can benefit from allogeneic hematopoietic stem cell transplantation (HSCT) or autologous HSCT. However, insufficient data about… read more here.
Keywords: d816v kit; mrd; runx1; runx1 runx1t1 ... See more keywords