RUNX2 interacts with SCD1 and activates Wnt/β‐catenin signaling pathway to promote the progression of clear cell renal cell carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Medicine"
DOI: 10.1002/cam4.5326
Abstract: Previous studies have demonstrated that Runt‐associated transcription factor 2 (RUNX2) serves as the main transcription factor for osteoblast differentiation and chondrocyte maturation. RUNX2 is related to a variety of tumors, particularly tumor invasion and metastasis,… read more here.
Keywords: cell renal; cell; cell carcinoma; renal cell ... See more keywords
RUNX2 co‐operates with EGR1 to regulate osteogenic differentiation through Htra1 enhancers
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.29704
Abstract: Runt‐related transcription factor 2 (Runx2) has been shown to regulate osteoblast differentiation by directly or indirectly regulating numerous osteoblast‐related genes. However, our understanding of the transcriptional mechanisms of RUNX2 is mainly restricted to its transactivation,… read more here.
Keywords: htra1 enhancers; runx2; differentiation; osteoblast differentiation ... See more keywords
Metformin protects against vascular calcification through the selective degradation of Runx2 by the p62 autophagy receptor
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30887
Abstract: Vascular calcification is associated with aging, type 2 diabetes, and atherosclerosis, and increases the risk of cardiovascular morbidity and mortality. It is an active, highly regulated process that resembles physiological bone formation. It has previously… read more here.
Keywords: calcification; vascular calcification; degradation; metformin ... See more keywords
Involvement of microRNA-23b in TNF-α-reduced BMSC osteogenic differentiation via targeting runx2
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Bone and Mineral Metabolism"
DOI: 10.1007/s00774-017-0886-8
Abstract: Elucidation of the molecular mechanism governing bone marrow mesenchymal stem cell (BMSC) osteogenic differentiation is of great importance for improving the treatment of osteoporosis. TNF-α is a well-known inhibitory factor during osteogenic differentiation of BMSCs.… read more here.
Keywords: runx2; tnf; bmsc osteogenic; mir 23b ... See more keywords
Transcription factor Runx2 changes the expression of some matricellular proteins in metastatic breast cancer cells.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular biology reports"
DOI: 10.1007/s11033-022-07457-3
Abstract: BACKGROUND Runx2 is one of the runt-related genes that are overexpressed in human cancers and contribute to metastasis. The cancer cell metastasis requires modifications of the extracellular matrix (ECM) and reduction in ECM-cell interaction. This… read more here.
Keywords: runx2; cancer; breast cancer; matricellular proteins ... See more keywords
Runx2 was Correlated with Neurite Outgrowth and Schwann Cell Differentiation, Migration After Sciatic Nerve Crush
Sign Up to like & getrecommendations! Published in 2018 at "Neurochemical Research"
DOI: 10.1007/s11064-018-2670-0
Abstract: Runx2, also known as Cbfa1, is a multifunctional transcription factor essential for osteoblast differentiation. It also plays major roles in chondrocyte maturation, mesenchymal stem cell differentiation, cleidocranial dysplasia, and the growth and metastasis of tumors.… read more here.
Keywords: schwann; runx2; cell differentiation; migration ... See more keywords
Osteoclast-derived miR-23a-5p-containing exosomes inhibit osteogenic differentiation by regulating Runx2.
Sign Up to like & getrecommendations! Published in 2019 at "Cellular signalling"
DOI: 10.1016/j.cellsig.2019.109504
Abstract: BACKGROUND Some microRNAs (miRNAs) are involved in osteogenic differentiation. In recent years, increasing evidences have revealed that exosomes contain specific miRNAs. However, the effect and mechanism of miR-23a-5p-containing exosomes in osteoblast remain largely unclear. METHODS… read more here.
Keywords: containing exosomes; runx2; 23a containing; osteogenic differentiation ... See more keywords
CBFβ promotes colorectal cancer progression through transcriptionally activating OPN, FAM129A, and UPP1 in a RUNX2-dependent manner.
Sign Up to like & getrecommendations! Published in 2021 at "Cell death and differentiation"
DOI: 10.1038/s41418-021-00810-2
Abstract: Colorectal cancer (CRC) is commonly associated with aberrant transcription regulation, but characteristics of the dysregulated transcription factors in CRC pathogenesis remain to be elucidated. In the present study, core-binding factor β (CBFβ) is found to… read more here.
Keywords: runx2; opn fam129a; colorectal cancer; cbf ... See more keywords
Osteogenic Factor Runx2 Marks a Subset of Leptin Receptor-Positive Cells that Sit Atop the Bone Marrow Stromal Cell Hierarchy
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-05401-1
Abstract: Bone marrow mesenchymal stem and progenitor cells (BM-MSPCs) maintain homeostasis of bone tissue by providing osteoblasts. Although several markers have been identified for labeling of MSPCs, these labeled cells still contain non-BM-MSPC populations. Studies have… read more here.
Keywords: runx2; cells sit; leptin receptor; bone ... See more keywords
Dmrt2 promotes transition of endochondral bone formation by linking Sox9 and Runx2
Sign Up to like & getrecommendations! Published in 2021 at "Communications Biology"
DOI: 10.1038/s42003-021-01848-1
Abstract: Endochondral bone formation is fundamental for skeletal development. During this process, chondrocytes undergo multiple steps of differentiation and coordinated transition from a proliferating to a hypertrophic stage, which is critical to advance skeletal development. Here,… read more here.
Keywords: bone formation; runx2; dmrt2; endochondral bone ... See more keywords
Stimulation of the Runx2 P1 promoter by collagen-derived dipeptide prolyl-hydroxyproline bound to Foxg1 and Foxo1 in osteoblasts
Sign Up to like & getrecommendations! Published in 2021 at "Bioscience Reports"
DOI: 10.1042/bsr20210304
Abstract: Abstract Collagen-derived dipeptide prolyl-hydroxyproline (Pro-Hyp) directly binds to the forkhead box g1 (Foxg1) protein and causes it to undergo structural alteration. Pro-Hyp also promotes the production of a regulator of osteoblast differentiation, Runt-related transcription factor… read more here.
Keywords: runx2; pro hyp; runx2 promoter; foxg1 foxo1 ... See more keywords