RUNX2 interacts with SCD1 and activates Wnt/β‐catenin signaling pathway to promote the progression of clear cell renal cell carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Medicine"
DOI: 10.1002/cam4.5326
Abstract: Previous studies have demonstrated that Runt‐associated transcription factor 2 (RUNX2) serves as the main transcription factor for osteoblast differentiation and chondrocyte maturation. RUNX2 is related to a variety of tumors, particularly tumor invasion and metastasis,… read more here.
Keywords: cell renal; cell; cell carcinoma; renal cell ... See more keywords
Melatonin promotes the proliferation and differentiation of antler chondrocytes via RUNX2 dependent on the interaction between NOTCH1 and SHH signaling pathways
Sign Up to like & getrecommendations! Published in 2024 at "Cell Biology International"
DOI: 10.1002/cbin.12272
Abstract: Melatonin (MT), an endogenous hormone secreted by pineal gland, has the sedative, anti‐inflammatory and antioxidant functions. However, there are few studies on whether MT affects the proliferation and differentiation of antler chondrocytes. The present study… read more here.
Keywords: differentiation; differentiation antler; antler chondrocytes; runx2 ... See more keywords
The Role of Runx2 in Microtubule Dynamics and Its Effects on Osteoblast Migration.
Sign Up to like & getrecommendations! Published in 2025 at "Cytoskeleton"
DOI: 10.1002/cm.70064
Abstract: The migration of osteoblasts (OBs) is crucial for bone formation, remodeling, and healing. This requires the coordinated activity of cytoskeletal components, including microtubules (MTs). MTs complement actin filaments by regulating focal adhesion turnover and facilitating… read more here.
Keywords: role runx2; migration; runx2 deficient; runx2 ... See more keywords
FGFR2‐RUNX2 activation: An unexplored therapeutic pathway in luminal breast cancer related to tumor progression
Sign Up to like & getrecommendations! Published in 2024 at "International Journal of Cancer"
DOI: 10.1002/ijc.35302
Abstract: Overcoming luminal breast cancer (BrCa) progression remains a critical challenge for improved overall patient survival. RUNX2 has emerged as a protein related to aggressiveness in triple‐negative BrCa, however its role in luminal tumors remains elusive.… read more here.
Keywords: brca; progression; fgfr2 runx2; tumor ... See more keywords
RUNX2 co‐operates with EGR1 to regulate osteogenic differentiation through Htra1 enhancers
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.29704
Abstract: Runt‐related transcription factor 2 (Runx2) has been shown to regulate osteoblast differentiation by directly or indirectly regulating numerous osteoblast‐related genes. However, our understanding of the transcriptional mechanisms of RUNX2 is mainly restricted to its transactivation,… read more here.
Keywords: htra1 enhancers; runx2; differentiation; osteoblast differentiation ... See more keywords
Metformin protects against vascular calcification through the selective degradation of Runx2 by the p62 autophagy receptor
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30887
Abstract: Vascular calcification is associated with aging, type 2 diabetes, and atherosclerosis, and increases the risk of cardiovascular morbidity and mortality. It is an active, highly regulated process that resembles physiological bone formation. It has previously… read more here.
Keywords: calcification; vascular calcification; degradation; metformin ... See more keywords
Hakai, a novel Runx2 interacting protein, augments osteoblast differentiation by rescuing Runx2 from Smurf2‐mediated proteasome degradation
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.31388
Abstract: Runt‐related transcription factor 2 (Runx2) is a key regulator of osteoblast differentiation and bone formation. In Runx2‐deficient embryos, skeletal development ceases at the cartilage anlage stage. These embryos die of respiratory failure upon birth and… read more here.
Keywords: smurf2 mediated; hakai; degradation; osteoblast differentiation ... See more keywords
Involvement of microRNA-23b in TNF-α-reduced BMSC osteogenic differentiation via targeting runx2
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Bone and Mineral Metabolism"
DOI: 10.1007/s00774-017-0886-8
Abstract: Elucidation of the molecular mechanism governing bone marrow mesenchymal stem cell (BMSC) osteogenic differentiation is of great importance for improving the treatment of osteoporosis. TNF-α is a well-known inhibitory factor during osteogenic differentiation of BMSCs.… read more here.
Keywords: runx2; tnf; bmsc osteogenic; mir 23b ... See more keywords
Transcription factor Runx2 changes the expression of some matricellular proteins in metastatic breast cancer cells.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular biology reports"
DOI: 10.1007/s11033-022-07457-3
Abstract: BACKGROUND Runx2 is one of the runt-related genes that are overexpressed in human cancers and contribute to metastasis. The cancer cell metastasis requires modifications of the extracellular matrix (ECM) and reduction in ECM-cell interaction. This… read more here.
Keywords: runx2; cancer; breast cancer; matricellular proteins ... See more keywords
Runx2 was Correlated with Neurite Outgrowth and Schwann Cell Differentiation, Migration After Sciatic Nerve Crush
Sign Up to like & getrecommendations! Published in 2018 at "Neurochemical Research"
DOI: 10.1007/s11064-018-2670-0
Abstract: Runx2, also known as Cbfa1, is a multifunctional transcription factor essential for osteoblast differentiation. It also plays major roles in chondrocyte maturation, mesenchymal stem cell differentiation, cleidocranial dysplasia, and the growth and metastasis of tumors.… read more here.
Keywords: schwann; runx2; cell differentiation; migration ... See more keywords
Osteoclast-derived miR-23a-5p-containing exosomes inhibit osteogenic differentiation by regulating Runx2.
Sign Up to like & getrecommendations! Published in 2019 at "Cellular signalling"
DOI: 10.1016/j.cellsig.2019.109504
Abstract: BACKGROUND Some microRNAs (miRNAs) are involved in osteogenic differentiation. In recent years, increasing evidences have revealed that exosomes contain specific miRNAs. However, the effect and mechanism of miR-23a-5p-containing exosomes in osteoblast remain largely unclear. METHODS… read more here.
Keywords: containing exosomes; runx2; 23a containing; osteogenic differentiation ... See more keywords