The Role of Runx2 in Microtubule Dynamics and Its Effects on Osteoblast Migration.
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DOI: 10.1002/cm.70064
Abstract: The migration of osteoblasts (OBs) is crucial for bone formation, remodeling, and healing. This requires the coordinated activity of cytoskeletal components, including microtubules (MTs). MTs complement actin filaments by regulating focal adhesion turnover and facilitating… read more here.
Keywords: role runx2; migration; runx2 deficient; runx2 ... See more keywords
Downregulation of Nesprin1 by Runx2 deficiency is critical for the development of skeletal laminopathy-like pathology
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DOI: 10.1073/pnas.2320138122
Abstract: Significance We identified a new laminopathy-like pathogenesis of cleidocranial dysplasia. Runx2 is a master transcription factor in osteogenesis. However, whether any immature osteoblast population emerges from Runx2-deficient cells is unclear. Single-cell RNA-seq analysis revealed that… read more here.
Keywords: laminopathy like; downregulation nesprin1; pathology; runx2 deficient ... See more keywords