Delayed tooth movement in Runx2+/− mice associated with mTORC2 in stretch-induced bone formation
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DOI: 10.1016/j.bonr.2020.100285
Abstract: Runt-related transcription factor 2 (Runx2) is an essential transcription factor for osteoblast differentiation, and is activated by mechanical stress to promote osteoblast function. Cleidocranial dysplasia (CCD) is caused by mutations of RUNX2, and CCD patients… read more here.
Keywords: movement; tooth movement; stretch induced; runx2 mice ... See more keywords
Different Requirements of CBFB and RUNX2 in Skeletal Development among Calvaria, Limbs, Vertebrae and Ribs
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DOI: 10.3390/ijms232113299
Abstract: RUNX proteins, such as RUNX2, regulate the proliferation and differentiation of chondrocytes and osteoblasts. Haploinsufficiency of RUNX2 causes cleidocranial dysplasia, but a detailed analysis of Runx2+/− mice has not been reported. Furthermore, CBFB is required… read more here.
Keywords: development; bone; cbfb2 mice; runx2 mice ... See more keywords