Cytoplasmic Localization of RUNX3 via Histone Deacetylase‐Mediated SRC Expression in Oxidative‐Stressed Colon Cancer Cells
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.25746
Abstract: Runt domain transcription factor 3 (RUNX3) is a transcription factor that functions as a tumor suppressor. RUNX3 is frequently inactivated by epigenetic silencing or its protein mislocalization (cytoplasmic localization) in many cancer types. This study… read more here.
Keywords: localization runx3; cytoplasmic localization; runx3; localization ... See more keywords
Runx3 regulates chondrocyte phenotype by controlling multiple genes involved in chondrocyte proliferation and differentiation
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Biology Reports"
DOI: 10.1007/s11033-020-05646-6
Abstract: Chondrocytes are the sole cell type present within cartilage, and play pivotal roles in controlling the formation and composition of health cartilage. Chondrocytes maintain cartilage homeostasis through proliferating, differentiating and synthesizing different types of extracellular… read more here.
Keywords: proliferation; differentiation; runx3; chondrocyte proliferation ... See more keywords
Aberrant methylation of RUNX3 is present in Aflatoxin B1-induced transformation of the L02R cell line.
Sign Up to like & getrecommendations! Published in 2017 at "Toxicology"
DOI: 10.1016/j.tox.2017.04.011
Abstract: Chronic exposure to aflatoxin B1 (AFB1) is linked to the development of hepatocellular carcinoma (HCC). To identify differentially methylated genes involved in AFB1-induced cell transformation, we analyzed DNA methylation patterns in immortal human hepatocyte L02… read more here.
Keywords: methylation; afb1; transformation; runx3 ... See more keywords
Runx3 plays a critical role in restriction-point and defense against cellular transformation
Sign Up to like & getrecommendations! Published in 2017 at "Oncogene"
DOI: 10.1038/onc.2017.290
Abstract: The restriction (R)-point decision is fundamental to normal differentiation and the G1–S transition, and the decision-making machinery is perturbed in nearly all cancer cells. The mechanisms underlying the cellular context–dependent R-point decision remain poorly understood.… read more here.
Keywords: plays critical; critical role; point; runx3 plays ... See more keywords
Small peptide inhibitor from the sequence of RUNX3 disrupts PAK1–RUNX3 interaction and abrogates its phosphorylation-dependent oncogenic function
Sign Up to like & getrecommendations! Published in 2021 at "Oncogene"
DOI: 10.1038/s41388-021-01927-x
Abstract: P21 Activated Kinase 1 (PAK1) is an oncogenic serine/threonine kinase known to play a significant role in the regulation of cytoskeleton and cell morphology. Runt-related transcription factor 3 (RUNX3) was initially known for its tumor… read more here.
Keywords: phosphorylation; threonine 209; runx3; small peptide ... See more keywords
Runx3 is required for oncogenic Myc upregulation in p53-deficient osteosarcoma
Sign Up to like & getrecommendations! Published in 2021 at "Oncogene"
DOI: 10.1038/s41388-021-02120-w
Abstract: Osteosarcoma (OS) in human patients is characterized by genetic alteration of TP53. Osteoprogenitor-specific p53-deleted mice (OS mice) have been widely used to study the process of osteosarcomagenesis. However, the molecular mechanisms responsible for the development… read more here.
Keywords: p53 deficient; p53; oncogenic myc; runx3 ... See more keywords
RUNX3 methylation drives hypoxia-induced cell proliferation and antiapoptosis in early tumorigenesis
Sign Up to like & getrecommendations! Published in 2020 at "Cell Death and Differentiation"
DOI: 10.1038/s41418-020-00647-1
Abstract: Inactivation of tumor suppressor Runt-related transcription factor 3 (RUNX3) plays an important role during early tumorigenesis. However, posttranslational modifications (PTM)-based mechanism for the inactivation of RUNX3 under hypoxia is still not fully understood. Here, we… read more here.
Keywords: methylation; cell proliferation; early tumorigenesis; runx3 ... See more keywords
MicroRNA-20a-5p regulates the epithelial-mesenchymal transition of human hepatocellular carcinoma by targeting RUNX3.
Sign Up to like & getrecommendations! Published in 2022 at "Chinese medical journal"
DOI: 10.1097/cm9.0000000000001975
Abstract: BACKGROUND MicroRNA-20a (miR-20a) is dysregulated in many types of malignancies, including human hepatocellular carcinoma (HCC), but its expression level and functional significance in HCC are still disputed. We aimed to study the role of miR-20a-5p… read more here.
Keywords: expression; hepatocellular carcinoma; runx3; hcc ... See more keywords
IL-12 Contributes to the Development of Asthma by Targeting HIF-1α/NLRP3 Pathway through Runx3
Sign Up to like & getrecommendations! Published in 2022 at "International Archives of Allergy and Immunology"
DOI: 10.1159/000526803
Abstract: Introduction: The aim of the study was to determine the role and mechanism of runt-related transcription factor 3 (Runx3) in the development of asthma. Methods: An asthma mouse model was constructed and validated by hematoxylin-eosin… read more here.
Keywords: development asthma; hif nlrp3; runx3; nlrp3 pathway ... See more keywords
Antitumor activity of RUNX3: Upregulation of E-cadherin and downregulation of the epithelial–mesenchymal transition in clear-cell renal cell carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Open Life Sciences"
DOI: 10.1515/biol-2022-0494
Abstract: Abstract RUNX3 is a transcription factor and tumor suppressor that is silenced or inactivated in diverse tumors. The effect of RUNX3 on the epithelial–mesenchymal transition in clear-cell renal cell carcinoma (CCRCC) remains unclear. We determined… read more here.
Keywords: cell; mesenchymal transition; ccrcc; runx3 ... See more keywords
Multi-Omics Analysis of the Prognostic and Immunological Role of Runt-Related Transcription Factor 3 in Pan-Cancer.
Sign Up to like & getrecommendations! Published in 2023 at "Critical reviews in eukaryotic gene expression"
DOI: 10.1615/critreveukaryotgeneexpr.2023044081
Abstract: Runt-related transcription factor 3 (RUNX3) plays a pivotal role in tumor microenvironment and immune infiltration. However, the prognostic and immunological roles of RUNX3 in pancancer remain unclear. In the current study, we explored the expression… read more here.
Keywords: immune infiltration; runx3; expression; analysis ... See more keywords