Bioprospection of anti‐inflammatory phytochemicals suggests rutaecarpine and quinine as promising 15‐lipoxygenase inhibitors
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.28634
Abstract: 15‐Lipoxygenase (15‐LOX) belongs to the family of nonheme iron containing enzymes that catalyzes the peroxidation of polyunsaturated fatty acids (PUFAs) to generate eicosanoids that play an important role in signaling pathways. The role of 15‐LOX… read more here.
Keywords: anti inflammatory; lipoxygenase; rut; rutaecarpine quinine ... See more keywords
3-B-RUT, a derivative of RUT, protected against alcohol-induced liver injury by attenuating inflammation and oxidative stress.
Sign Up to like & getrecommendations! Published in 2021 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2021.107471
Abstract: Alcoholic liver disease (ALD) is the most common chronic liver disease worldwide. Currently, there is no definitive treatment for alcohol-induced liver injury (ALI). Inflammatory response and oxidative stress play a crucial role in ALI. Cyclooxygenase… read more here.
Keywords: liver injury; alcohol induced; rut; oxidative stress ... See more keywords
Study on the Rut Control Threshold of Asphalt Pavement Considering Steering Stability of Autonomous Vehicles Based on Fuzzy Control Theory
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DOI: 10.1155/2021/8879900
Abstract: To fully consider the impact of asphalt pavement rut on steering stability of autonomous vehicles, the sensitivity of various indicators of rut shape to vehicle stability was comprehensively measured, and pavement rut control standards based… read more here.
Keywords: rut depth; control; vehicle; rut ... See more keywords
Fluorine-Modified Rutaecarpine Exerts Cyclooxygenase-2 Inhibition and Anti-inflammatory Effects in Lungs
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2019.00091
Abstract: Inflammation is the first step that leads to inflammatory cell migration, cytokine release, and myofibroblast formation. Myofibroblasts can deposit excess amounts of extracellular matrix. Cyclooxygenase (COX) inhibitor exhibits strong anti-inflammatory response; however, this is usually… read more here.
Keywords: anti inflammatory; cyclooxygenase; modified rutaecarpine; rut ... See more keywords
Rutin bioconjugates as potential nutraceutical prodrugs: An in vitro and in ovo toxicological screening
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.1000608
Abstract: Rutin (RUT) is considered one the most attractive flavonoids from a therapeutic perspective due to its multispectral pharmacological activities including antiradical, anti-inflammatory, antiproliferative, and antimetastatic among others. Still, this compound presents a low bioavailability what… read more here.
Keywords: rut; ovo toxicological; vitro ovo; cell lines ... See more keywords
Rutaecarpine suppresses the proliferation and metastasis of colon cancer cells by regulating the STAT3 signaling
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cancer"
DOI: 10.7150/jca.66177
Abstract: Colorectal cancer (CRC) is a malignant disease that is a serious threat to human health. Rutaecarpine (RUT) is an important bioactive alkaloid of Evodia rutaecarpa. According to previous studies, RUT suppressed the proliferation of several… read more here.
Keywords: crc cells; rut; rutaecarpine; stat3 signaling ... See more keywords