Pr2O3 Supported Nano‐layered Ruthenium Catalyzed Acceptorless Dehydrogenative Synthesis of 2‐Substituted Quinolines and 1,8‐Naphthyridines from 2‐Aminoaryl Alcohols and Ketones
Sign Up to like & getrecommendations! Published in 2020 at "ChemCatChem"
DOI: 10.1002/cctc.201902311
Abstract: Pr2O3 supported Ru nanolayers and Ru nanoparticles catalysts were examined for the synthesis of quinolines. The Ru nanolayer was most active catalyst and showed a broad substrate scope. Structure‐activity relationship demonstrated that the metallic state… read more here.
Keywords: supported nano; pr2o3 supported; nano layered; ruthenium catalyzed ... See more keywords
Ruthenium‐Catalyzed Cycloaddition for Introducing Chemical Diversity in Second‐Generation β‐Lactamase Inhibitors
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DOI: 10.1002/cmdc.202300077
Abstract: Ruthenium(II) alkyne azide cycloaddition (RuAAC) is an attractive reaction to access 1,5‐triazole derivatives and is applicable to internal alkynes. Here, we explore RuAAC to introduce molecular diversity on the diazabicyclooctane (DBO) scaffold of β‐lactamase inhibitors.… read more here.
Keywords: catalyzed cycloaddition; ruthenium catalyzed; lactamase inhibitors; diversity ... See more keywords
Ruthenium-catalyzed dimerization of CF3-containing functional allenes
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Organometallic Chemistry"
DOI: 10.1016/j.jorganchem.2021.121998
Abstract: Abstract An efficient method for the regioselective preparation of 1,3-dimethylenecyclobutanes based on Ru-catalyzed dimerization of readily available CF3-containing functionalized allenes including α-amino acid derivatives have been developed. The reactions smoothly proceed in toluene at 100… read more here.
Keywords: catalyzed dimerization; ruthenium catalyzed; cf3 containing;
Ruthenium(II)-catalyzed facile synthesis of 3-(phenylamino)-1H-indole-2-carboxylates from anilines and diazo pyruvates promoted by FeCl3
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DOI: 10.1016/j.tet.2020.131399
Abstract: Abstract An unprecedented synthetic route towards a variety of 3-anilino-1H-indoles is accomplished from diazo pyruvates and anilines via a domino ruthenium-catalyzed annulation and subsequent iron promoted fragmentation and rearrangement. The current strategy was amenable to… read more here.
Keywords: catalyzed facile; facile synthesis; ruthenium catalyzed; diazo pyruvates ... See more keywords
Ruthenium-Catalyzed Urea Synthesis by N-H Activation of Amines.
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DOI: 10.1021/acs.inorgchem.7b00962
Abstract: Activation of the N-H bond of amines by a ruthenium pincer complex operating via "amine-amide" metal-ligand cooperation is demonstrated. Catalytic formyl C-H activation of N,N-dimethylformamide (DMF) is observed in situ, which resulted in the formation… read more here.
Keywords: activation amines; amines ruthenium; activation; ruthenium catalyzed ... See more keywords
Ruthenium(II)-Catalyzed Ortho-C-H Alkylation of Naphthylamines with Diazo Compounds for Synthesis of 2,2-Disubstituted π-Extended 3-Oxindoles in Water.
Sign Up to like & getrecommendations! Published in 2020 at "Organic letters"
DOI: 10.1021/acs.orglett.0c01811
Abstract: Ruthenium(II)-catalyzed ortho-C-H alkylation of naphthylamines with diazo compounds for the synthesis of 2,2-disubstituted π-extended 3-oxindoles has been developed. The method represents the first example of C-H alkylation via carbenoid insertion in water as a sustainable… read more here.
Keywords: catalyzed ortho; naphthylamines diazo; alkylation naphthylamines; alkylation ... See more keywords
Ruthenium-Catalyzed PIII-Directed Remote ε-C-H Alkylation of Phosphines.
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DOI: 10.1021/acs.orglett.0c03906
Abstract: The ruthenium-catalyzed remote ε-C-H alkylation of phosphines with tertiary alkyl halides has been developed. This novel PIII-directed C-H activation strategy tolerated various functional groups and delivered a wide variety of modified phosphines with excellent meta-site… read more here.
Keywords: piii directed; alkylation phosphines; remote alkylation; catalyzed piii ... See more keywords
Ruthenium(II)-Catalyzed Chelation-Assisted Desulfitative Arylation of Benzo[h]quinolines with Arylsulfonyl Chlorides.
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DOI: 10.1021/acs.orglett.2c00542
Abstract: Herein, a novel chelation-assisted C-H arylation reaction of benzo[h]quinoline is described. This transformation, using [RuCl2(p-cymene)]2 as the catalyst and cheap and easily accessible arylsulfonyl chlorides as the arylation source, featured simple reaction conditions, a broad… read more here.
Keywords: arylation; desulfitative arylation; ruthenium catalyzed; arylsulfonyl chlorides ... See more keywords
Ruthenium-Catalyzed Divergent Acceptorless Dehydrogenative Coupling of 1,3-Diols with Arylhydrazines: Synthesis of Pyrazoles and 2-Pyrazolines.
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DOI: 10.1021/acs.orglett.2c01497
Abstract: Herein, the divergent transformations of 1,3-diols with arylhydrazines via acceptorless dehydrogenative coupling reactions to selectively synthesize pyrazoles and 2-pyrazolines were reported, which were based on Ru3(CO)12/NHC-phosphine-phosphine catalytic systems. The reactions featured low catalyst loading, high… read more here.
Keywords: ruthenium catalyzed; pyrazoles pyrazolines; diols arylhydrazines; acceptorless dehydrogenative ... See more keywords
Ruthenium-Catalyzed 1,3-Aryl Redox Isomerization of Allylic Alcohols.
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DOI: 10.1021/acs.orglett.2c03410
Abstract: The isomerization of allylic alcohols to the corresponding carbonyl compounds is a well-established reaction in organic synthesis. However, 1,3-carbon migration is a quite challenging field, and thus transformation has remained elusive until now. Herein, we… read more here.
Keywords: ruthenium catalyzed; isomerization; aryl redox; allylic alcohols ... See more keywords
Ruthenium-Catalyzed Ligand-Enabled Regiodivergent Difluoroallylation of Aryl C-H Bonds.
Sign Up to like & getrecommendations! Published in 2023 at "Organic letters"
DOI: 10.1021/acs.orglett.3c00873
Abstract: The gem-difluoroallyl group is a sought-after structural motif commonly found in pharmaceutical compounds. Despite its appeal, achieving a controlled synthesis of both α,α- and γ,γ-difluoroallylated compounds has proven to be a challenging task. This study… read more here.
Keywords: catalyzed ligand; ligand enabled; regiodivergent difluoroallylation; ruthenium catalyzed ... See more keywords