Design, synthesis and evaluation of anticancer activity of ruthenium (II) polypyridyl complexes.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of inorganic biochemistry"
DOI: 10.1016/j.jinorgbio.2017.04.028
Abstract: A new ligand PFPIP (PFPIP=2-(2,3,4,5,6-pentafluorophenyl)[4,5-f]imadazo [1,10]phenanthroline) and its four ruthenium(II) polypyridyl complexes [Ru(NN)2(PFPIP)](ClO4)2 (NN=dmb: 4,4'-dimethyl-2,2'-bipyridine, 1; bpy: 2,2'-bipyridine, 2; phen: 1,10-phenanthroline, 3; dmp: 2,9-dimethyl-1,10-phenanthroline, 4) were synthesized and characterized by elemental analysis, IR, 1H NMR,… read more here.
Keywords: polypyridyl complexes; cell; ruthenium polypyridyl; bel 7402 ... See more keywords
Diatom-like silica-protein nanocomposites for sustained drug delivery of ruthenium polypyridyl complexes.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of inorganic biochemistry"
DOI: 10.1016/j.jinorgbio.2021.111489
Abstract: Inspired by the unique glass cell wall of diatom, we design a new nanostructure of human serum albumin nanoparticle (HSANP) coated with silica (HSA/SiO2), which consists of a core-satellite assembly of small silica nanoparticles on… read more here.
Keywords: drug; drug delivery; ruthenium polypyridyl; hsa sio2 ... See more keywords
Ruthenium(II) Polypyridyl Complexes Coordinated Directly to the Pyrrole Backbone of π-Extended Boron Dipyrromethene (Bodipy) Dyes: Synthesis, Characterization, and Spectroscopic and Electrochemical Properties.
Sign Up to like & getrecommendations! Published in 2017 at "Inorganic chemistry"
DOI: 10.1021/acs.inorgchem.7b01630
Abstract: A series of new Bodipy dyes incorporating the π-extended isoquino[5,6-c]pyrrole have been synthesized and characterized. The dyes display intense Bodipy (π-π*) transitions and emissions with high quantum efficiencies. Spectroscopic, electrochemical, and theoretical calculations are used… read more here.
Keywords: polypyridyl complexes; spectroscopic electrochemical; ruthenium polypyridyl; bodipy dyes ... See more keywords
Diastereoselective Synthesis and Two-Step Photocleavage of Ruthenium Polypyridyl Complexes Bearing a Bis(thioether) Ligand
Sign Up to like & getrecommendations! Published in 2019 at "Inorganic Chemistry"
DOI: 10.1021/acs.inorgchem.9b01669
Abstract: Thioethers are good ligands for photoactivatable ruthenium(II) polypyridyl complexes, as they form thermally stable complexes that are prone to ligand photosubstitution. Here, we introduce a novel symmetric chelating bis(thioether) ligand scaffold, based on 1,3-bis(methylthio)-2-propanol (4)… read more here.
Keywords: ruthenium; bis thioether; ruthenium polypyridyl; bis ... See more keywords
Ruthenium(II) Polypyridyl Complexes as FRET Donors: Structure- and Sequence-Selective DNA-Binding and Anticancer Properties
Sign Up to like & getrecommendations! Published in 2023 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c11111
Abstract: Ruthenium(II) polypyridyl complexes (RPCs) that emit from metal-to-ligand charge transfer (MLCT) states have been developed as DNA probes and are being examined as potential anticancer agents. Here, we report that MLCT-emissive RPCs that bind DNA… read more here.
Keywords: dna; ruthenium polypyridyl; anticancer properties; dna binding ... See more keywords
Designing Photolabile Ruthenium Polypyridyl Crosslinkers for Hydrogel Formation and Multiplexed, Visible-light Degradation.
Sign Up to like & getrecommendations! Published in 2019 at "RSC advances"
DOI: 10.1039/c8ra09764j
Abstract: Photoresponsive materials afford spatiotemporal control over desirable physical, chemical and biological properties. For advanced applications, there is need for molecular phototriggers that are readily incorporated within larger structures, and spatially-sequentially addressable with different wavelengths of… read more here.
Keywords: ruthenium polypyridyl; hydrogel formation; designing photolabile;
Balancing the interplay between ligand ejection and therapeutic window light absorption in ruthenium polypyridyl complexes.
Sign Up to like & getrecommendations! Published in 2022 at "Dalton transactions"
DOI: 10.1039/d2dt01237e
Abstract: Ruthenium polypyridyl complexes have gained significant interest as photochemotherapies (PCTs) where their excited-state properties play a critical role in the photo-cytotoxicity mechanism and efficacy. Herein we report a systematic electrochemical, spectrochemical, and photophysical analysis of… read more here.
Keywords: ruthenium polypyridyl; polypyridyl; ligand; therapeutic window ... See more keywords
8-Hydroxyquinoline-modified ruthenium(II) polypyridyl complexes for JMJD inhibition and photodynamic antitumor therapy.
Sign Up to like & getrecommendations! Published in 2022 at "Dalton transactions"
DOI: 10.1039/d2dt01765b
Abstract: As an ideal scaffold for metal ion chelation, 8-hydroxyquinoline (8HQ) can chelate different metal ions, such as Fe2+, Cu2+, Zn2+, etc. Here, by integrating 8HQ with a ruthenium(II) polypyridyl moiety, two Ru(II)-8HQ complexes (Ru1 and… read more here.
Keywords: antitumor; ruthenium polypyridyl; ru2; ru1 ru2 ... See more keywords
Ruthenium(II) Polypyridyl Complexes with π‑Expansive Ligands: Synthesis and Cubosome Encapsulation for Photodynamic Therapy of Non-Melanoma Skin Cancer
Sign Up to like & getrecommendations! Published in 2023 at "Inorganic Chemistry Frontiers"
DOI: 10.1039/d2qi02678c
Abstract: In photodynamic therapy (PDT), Ru(II) polypyridyl complexes (RPCs) featuring the popular π-expansive benzo[i]dipyrido[3,2-a:2′,3′-c]phenazine (dppn) ligand have attracted much attention, mainly due to the good singlet oxygen sensitizing properties imparted by... read more here.
Keywords: ruthenium polypyridyl; complexes expansive; photodynamic therapy; polypyridyl complexes ... See more keywords
Synthesis and evaluation of four novel nitrogen-heterocyclic ruthenium polypyridyl complexes as photosensitizers for one and two-photon photodynamic therapy.
Sign Up to like & getrecommendations! Published in 2023 at "Dalton transactions"
DOI: 10.1039/d3dt00537b
Abstract: Four novel PSs (photosensitizers) of nitrogen-heterocyclic ruthenium polypyridyl complexes Ru(dip)2(o-pipppz)(PF6)2 (Ru1) (dip = 4,7-diphenyl-1,10-phenanthroline; o-pipppz = 1-(4-aldehydephenyl)-3-(pyridazyl-2-yl)-1H-pyrazole), Ru(dip)2(o-pipp) (PF6)2 (Ru2) (o-pipp = 1-(4-aldehydephenyl)-3-(pyrid-2-yl)-1H-pyrazole), Ru(dip)2(m-pipp)(PF6)2 (Ru3) (m-pipp = 1-(4-aldehydephenyl)-3-(pyrid-3-yl)-1H-pyrazole) and Ru(dip)2(p-pipp)(PF6)2 (Ru4) (p-pipp = 1-(4-aldehydephenyl)-3-(pyrid-4-yl)-1H-pyrazole) were… read more here.
Keywords: nitrogen heterocyclic; heterocyclic ruthenium; ruthenium polypyridyl; pipp ... See more keywords
In vitro cytotoxicity, cellular uptake, reactive oxygen species and cell cycle arrest studies of novel ruthenium(II) polypyridyl complexes towards A549 lung cancer cell line
Sign Up to like & getrecommendations! Published in 2019 at "Drug and Chemical Toxicology"
DOI: 10.1080/01480545.2019.1589492
Abstract: Abstract Ruthenium(II) polypyridyl complexes have displayed some promising biological responses against a variety of cancers and have emerged as a potential candidate that can show significant antitumor activity. Three ruthenium(II) polypyridyl complexes were biologically evaluated… read more here.
Keywords: polypyridyl complexes; cell; ruthenium polypyridyl; cytotoxicity ... See more keywords