Emergent composite structures following the amorphization of itraconazole with α-glucosyl rutin by over-grinding
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DOI: 10.1016/j.powtec.2017.10.002
Abstract: Abstract We investigated the use of α-glucosyl rutin (rutin-G) as a grinding aid for wet bead milling. Itraconazole (ITCZ), which has low solubility at physiological pH conditions, was used as a model poorly water-soluble drug.… read more here.
Keywords: rutin grinding; itcz; glucosyl rutin; composite structures ... See more keywords