Characterizing the mitochondrial DNA polymerase gamma interactome by BioID identifies Ruvbl2 localizes to the mitochondria.
Sign Up to like & getrecommendations! Published in 2017 at "Mitochondrion"
DOI: 10.1016/j.mito.2016.11.001
Abstract: Human mitochondrial DNA (mtDNA) is replicated by the mitochondrial DNA polymerase gamma (POLG). Using proximity dependent biotin labelling (BioID), we characterized the POLG interactome and identified new interaction partners involved in mtDNA maintenance, transcription, translation… read more here.
Keywords: dna; dna polymerase; polymerase gamma; ruvbl2 ... See more keywords
Chemical perturbations reveal that RUVBL2 regulates the circadian phase in mammals
Sign Up to like & getrecommendations! Published in 2020 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.aba0769
Abstract: A compound that disassembles the circadian repressive super-complex can reset circadian phase and relieve jet lag in mice. Shifting clock gears Molecular circadian oscillators help control sleep/wake periodicity. Ju et al. show that an AAA-type… read more here.
Keywords: phase; circadian phase; ruvbl2; clock ... See more keywords
Ruvbl2 Suppresses Cardiomyocyte Proliferation During Zebrafish Heart Development and Regeneration
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.800594
Abstract: Cardiomyocyte proliferation is an important source of new myocardium during heart development and regeneration. Consequently, mutations in drivers of cardiomyocyte proliferation cause congenital heart disease, and infarcted human hearts scar because cardiomyocytes exit the cell… read more here.
Keywords: regeneration; heart development; cardiomyocyte proliferation; ruvbl2 ... See more keywords