Cannabinoid type 2 receptor agonist JWH133 decreases blood pressure of spontaneously hypertensive rats through relieving inflammation in the rostral ventrolateral medulla of the brain.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Hypertension"
DOI: 10.1097/hjh.0000000000002342
Abstract: OBJECTIVE Neuroinflammation in the rostral ventrolateral medulla (RVLM) has been reported to be associated with hypertension. The upregulation and activation of the cannabinoid type 2 (CB2) receptor may be part of the active process of… read more here.
Keywords: jwh133; cb2 receptor; rvlm; receptor ... See more keywords
Somatostatin 2 Receptor Activation in the Rostral Ventrolateral Medulla Does Not Mediate the Decompensatory Phase of Haemorrhage
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DOI: 10.1097/shk.0000000000001011
Abstract: ABSTRACT Decompensation, a critical phase in the response to hemorrhage, is characterized by profound sympathoinhibition and the overriding of baroreflex mediated compensation. As sympathoexcitatory neurons of the rostral ventrolateral medulla (RVLM) maintain vasomotor tone and… read more here.
Keywords: ventrolateral medulla; receptor; somatostatin; decompensation ... See more keywords
Cardiorespiratory alterations following intermittent photostimulation of RVLM C1 neurons: Implications for long‐term blood pressure, breathing and sleep regulation in freely moving rats
Sign Up to like & getrecommendations! Published in 2022 at "Acta Physiologica"
DOI: 10.1111/apha.13864
Abstract: Sympathoexcitation and sleep‐disordered breathing are common contributors for disease progression. Catecholaminergic neurons from the rostral ventrolateral medulla (RVLM‐C1) modulate sympathetic outflow and have anatomical projections to respiratory neurons; however, the contribution of highly selective activation… read more here.
Keywords: long term; cardiorespiratory alterations; rvlm neurons; regulation ... See more keywords
Effect of oxidative stress in rostral ventrolateral medulla on sympathetic hyperactivity after traumatic brain injury
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DOI: 10.1111/ejn.14374
Abstract: Sympathetic hyperactivity occurs in a subgroup of patients after traumatic brain injury (TBI). The rostral ventrolateral medulla (RVLM) is a key region for the activity of sympathetic nervous system. Oxidative stress in the RVLM is… read more here.
Keywords: oxidative stress; stress; injury; rvlm ... See more keywords
Wheat Germ Supplementation Attenuates Obesity-Induced Neuroinflammation in the RVLM of IL-10 KO mice
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5731095
Abstract: Obesity is known to be a major factor in the increase of cardiovascular risk and inflammatory responses in the brain. It has been found that high-fat diet (HFD)-induced obesity increases sympathetic nerve activity (SNA) through… read more here.
Keywords: supplementation; physiology; rvlm; obesity ... See more keywords
Selective Nrf2 Overexpression in the RVLM ameliorates Obesity-induced Sympathoexcitation
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5731842
Abstract: The rostral part of the ventrolateral medulla (RVLM) in the brainstem is an important region responsible for both the resting levels and the reflex control of sympathetic nerve activity (SNA). Oxidative stress-induced hyperactivation of the… read more here.
Keywords: control; nrf2 overexpression; physiology; vector ... See more keywords
BDNF-related mechanisms of neuroplasticity in the rostral ventrolateral medulla of sedentary versus active rats
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5731939
Abstract: Overactivity of the sympathetic nervous system is implicated in cardiovascular disease (CVD), the leading cause of death. Sympathetic nerve activity is regulated by a region in the brainstem, the rostral ventrolateral medulla (RVLM). The RVLM… read more here.
Keywords: active rats; sedentary active; neuroplasticity; rostral ventrolateral ... See more keywords
Sympathetic pressor responses to glutamate nanoinjections in the rostral ventrolateral medulla are influenced by ovarian hormones in active but not sedentary female rats
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5733908
Abstract: Cardiovascular disease (CVD) is the leading cause of death worldwide. One of the leading risk factors for CVD is hypertension. The incidence of hypertension in females increases drastically after the onset of menopause, suggesting female… read more here.
Keywords: pressor responses; female rats; physiology; ovarian hormones ... See more keywords
Neuroinflammation and Microglial Activation at Rostral Ventrolateral Medulla Underpin Cadmium-Induced Cardiovascular Dysregulation in Rats
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DOI: 10.2147/jir.s325528
Abstract: Purpose Cadmium is a heavy metal and environmental toxicant known to act on the central cardiovascular regulatory mechanisms, and one of its brain targets is the rostral ventrolateral medulla (RVLM), a brainstem site that maintains… read more here.
Keywords: microglial activation; activation; cadmium; rvlm ... See more keywords
Identifying Increases in Activity of the Human RVLM Through MSNA-Coupled fMRI
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DOI: 10.3389/fnins.2019.01369
Abstract: Aim We initially developed concurrent recording of muscle sympathetic nerve activity (MSNA) and functional magnetic resonance imaging (fMRI) of the brain to functionally identify the human homolog of the rostral ventrolateral medulla (RVLM). Here we… read more here.
Keywords: coupled fmri; msna; signal intensity; msna coupled ... See more keywords
β-Arrestin1 Reduces Oxidative Stress via Nrf2 Activation in the Rostral Ventrolateral Medulla in Hypertension
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2021.657825
Abstract: Oxidative stress in the rostral ventrolateral medulla (RVLM), a key region for blood pressure (BP) regulation, has been demonstrated to be responsible for the overactivity of the sympathetic nervous system in hypertension and heart failure.… read more here.
Keywords: stress; arrestin1; nrf2 activation; rvlm ... See more keywords